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The patients were randomized to conventional corneal crosslinking (<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a030) or corneal crosslinking with mechanical compression using a flat rigid contact lens sutured to the cornea during treatment (<jats:styled-content style=\"fixed-case\">CRXL<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a030). Subjective refraction and <jats:styled-content style=\"fixed-case\">ETDRS<\/jats:styled-content> best spectacle\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BSCVA<\/jats:styled-content>), axial length measurement, keratometry and pachymetry were performed before and 1 and 6\u00a0months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The keratoconus patients had poorer <jats:styled-content style=\"fixed-case\">BSCVA<\/jats:styled-content>, higher refractive astigmatism and higher keratometry readings than the control subjects at baseline (p\u00a0&lt;\u00a00.01). In the <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> group, <jats:styled-content style=\"fixed-case\">BSCVA<\/jats:styled-content> increased from 0.19\u00a0\u00b1\u00a00.26 to 0.14\u00a0\u00b1\u00a00.18 logMar (p\u00a0=\u00a00.03), and the spherical equivalent improved from \u22121.9\u00a0\u00b1\u00a02.8\u00a0D to \u22121.4\u00a0\u00b1\u00a02.4\u00a0D (p\u00a0=\u00a00.03). Maximum keratometry readings decreased after <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> from 53.1\u00a0\u00b1\u00a04.9\u00a0D to 52.6\u00a0\u00b1\u00a05.2\u00a0D (p\u00a0=\u00a00.02), and the axial length decreased in the <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> group, likely due to post\u2010treatment corneal thinning (p\u00a0=\u00a00.03). In the <jats:styled-content style=\"fixed-case\">CRXL<\/jats:styled-content> group, all the above variables were unaltered (p\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 6\u00a0months, the refractive results from <jats:styled-content style=\"fixed-case\">CRXL<\/jats:styled-content> did not surpass those of conventional <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> treatment. Rather, some variables indicated a slightly inferior effect. Possibly, stronger crosslinking would be necessary to stabilize the cornea in the flattened configuration achieved by the rigid contact lens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12380","type":"journal-article","created":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T05:14:41Z","timestamp":1394860481000},"page":"644-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Initial results from mechanical compression of the cornea during crosslinking for keratoconus"],"prefix":"10.1111","volume":"92","author":[{"given":"Jeannette","family":"Beckman Rehnman","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Ophthalmology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Behndig","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ophthalmology Ume\u00e5 University Ume\u00e5 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