{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:57:05Z","timestamp":1791403025367,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"The Japanese Ministry of Health, Labor and Welfare."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the clinical efficacy of cultivated oral mucosal epithelial transplantation (<jats:styled-content style=\"fixed-case\">COMET<\/jats:styled-content>) for the treatment of persistent epithelial defect (<jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We treated 10 eyes of nine patients with <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> (Stevens\u2013Johnson syndrome: three eyes; thermal\/chemical injury: five eyes; ocular cicatricial pemphigoid: two eyes) with <jats:styled-content style=\"fixed-case\">COMET<\/jats:styled-content> at <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>yoto <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>refectural <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicine, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>yoto, <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan from 2002 to 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperatively, <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> existed on over more than 50% of the corneal surface in seven eyes. Severe ocular surface inflammation with fibrovascular tissue surrounded the <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> in all 10 eyes. At 24\u2010weeks postoperative, <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> had improved in all cases except 1 in which the patient was unable to return to the hospital (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 55.5\u201399.7; Wilcoxon signed\u2010rank test, p\u00a0=\u00a00.0078). The preoperative median of logarithmic minimum angle of resolution was 1.85 (range 0.15\u20132.70), and 1.85, 1.85, and 1.52 at the 4th, 12th, and 24th postoperative week, respectively. The mean total preoperative ocular surface grading score was 7.0 (range 4\u201317). At 4 and 12\u00a0weeks postoperative, the total ocular surface grading score had improved significantly (p<jats:italic>\u00a0<\/jats:italic>=\u00a00.0020, p<jats:italic>\u00a0<\/jats:italic>=\u00a00.0078), and at 24 weeks postoperative, it was 3.0 (range 2\u201312, p\u00a0=\u00a00.0234). During the follow\u2010up period (median 23.3\u00a0months, range 5.6\u201339.7\u00a0months), no recurrence of <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> was observed in any eye, and long\u2010term ocular surface stability was obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">COMET<\/jats:styled-content> enabled complete epithelialization of <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> and stabilization of the ocular surface in patients with severe ocular surface disease, thus preventing end\u2010stage cicatrization and vision loss at a later stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12397","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T06:02:03Z","timestamp":1400479323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Cultivated oral 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