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The association between the choroidal thickness and the presence of primary angle closure was evaluated using logistic regression models to determine the odds ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary angle\u2010closure eyes had a thicker choroid than the control eyes at all macular locations (all p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). It remained significantly thicker after controlling for age, axial length (<jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>) and gender, except at 1\u00a0mm, 3\u00a0mm superior and 3\u00a0mm nasal from the fovea. Univariate analysis showed that the subfoveal choroidal thickness (<jats:styled-content style=\"fixed-case\">SFCT<\/jats:styled-content>) was significantly associated with primary angle closure. After adjustment for the anterior chamber depth (<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>), vitreous chamber depth (<jats:styled-content style=\"fixed-case\">VCD<\/jats:styled-content>) and lens thickness (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>), the <jats:styled-content style=\"fixed-case\">SFCT<\/jats:styled-content> was still significantly associated with primary angle closure. The odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) was 1.008 (1.003, 1.014). The choroidal thickness at most macular locations was positively associated with primary angle closure. The area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) for detecting primary angle closure was 0.619 with <jats:styled-content style=\"fixed-case\">SFCT<\/jats:styled-content>, and the result was statistically significant (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary angle\u2010closure eyes have a higher level of macular choroidal thickness than normal eyes. Increased choroidal thickness might be association with primary angle closure. However, the <jats:styled-content style=\"fixed-case\">SFCT<\/jats:styled-content> showed only low specificity in screening for primary angle closure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12403","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T02:47:24Z","timestamp":1396493244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Is increased choroidal thickness association with primary angle closure?"],"prefix":"10.1111","volume":"92","author":[{"given":"Minwen","family":"Zhou","sequence":"first","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Gao","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Affiliated 1st People's Hospital of Chenzhou City Nanhua University Chenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Li","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,2]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Preferred Practice Pattern\u00ae Guidelines. 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