{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:02:51Z","timestamp":1792184571566,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n To examine the circadian intraocular pressure (\n IOP<\/jats:styled-content>\n ) patterns in healthy subjects, in primary open angle and normal tension glaucoma (\n POAG<\/jats:styled-content>\n ;\n NTG<\/jats:styled-content>\n ) using a contact lens sensor (\n CLS<\/jats:styled-content>\n ; Sensimed Triggerfish, Lausanne, Switzerland).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was an observational, nonrandomized study. Ten healthy subjects (Group 1, 10 eyes) and 20 glaucomatous patients [20 eyes, 10 with\n POAG<\/jats:styled-content>\n (Group 2) and 10 with\n NTG<\/jats:styled-content>\n (Group 3)] were enrolled. All patients were controlled with prostaglandin analogues. The 24\u2010hr\n IOP<\/jats:styled-content>\n pattern was the main outcome. The morning (6\n AM<\/jats:styled-content>\n \u201311\n AM<\/jats:styled-content>\n ), afternoon\/evening (noon\u201011\n PM<\/jats:styled-content>\n ) and night (midnight\u20105\n AM<\/jats:styled-content>\n ) subperiod patterns, peaks and prolonged peaks (>1\u00a0hr) were secondary outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean 24\u2010hr\n IOP<\/jats:styled-content>\n pattern showed a nocturnal acrophase in all groups. Patterns were significantly different among groups (p\u00a0=\u00a00.02), with highest nocturnal\n IOP<\/jats:styled-content>\n values in\n POAG<\/jats:styled-content>\n . Prolonged peaks were more common in patients with glaucoma (70%) than in healthy subjects (33.3%) (p\u00a0<\u00a00.001). Significant differences were found for Groups 2 and 3 in the morning versus afternoon\/evening (p\u00a0=\u00a00.019 and p\u00a0=\u00a00.035, Bonferroni correction), morning versus night (p\u00a0=\u00a00.005 and p\u00a0<\u00a00.0001) and afternoon\/evening versus night periods comparisons (p\u00a0<\u00a00.0001 for both groups). In Group 1, patterns significantly differed in the morning versus night and afternoon\/evening versus night period comparisons (p\u00a0<\u00a00.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Continuous 24\u2010hr\n IOP<\/jats:styled-content>\n monitoring with the\n CLS<\/jats:styled-content>\n revealed a nocturnal acrophase in healthy subjects and, more markedly, in glaucoma. Because the diurnal\n IOP<\/jats:styled-content>\n profile seems not to predict the nocturnal rhythm, the circadian\n IOP<\/jats:styled-content>\n pattern should be evaluated in clinical practice. These findings may be worthwhile for the management of glaucoma.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.12408","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T07:28:09Z","timestamp":1397114889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Circadian intraocular pressure patterns in healthy subjects, primary open angle and normal tension glaucoma patients with a contact lens sensor"],"prefix":"10.1111","volume":"93","author":[{"given":"Luca","family":"Agnifili","sequence":"first","affiliation":[{"name":"Department of Medicine and Aging Science Ophthalmology Clinic University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Mastropasqua","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Department of Neurological Neuropsychological, Morphological and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Frezzotti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience Ophthalmology Clinic University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Fasanella","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Science Ophthalmology Clinic University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Motolese","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience Ophthalmology Clinic University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Pedrotti","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Department of Neurological Neuropsychological, Morphological and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Di","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Science Laboratory of Clinical Epidemiology and Aging University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Mattei","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Science Ophthalmology Clinic University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Motolese","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience Ophthalmology Clinic University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Mastropasqua","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Science Ophthalmology Clinic University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Basic and Clinical Science Course","author":"American Academy of Ophthalmology.","year":"2006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200004000-00002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.6.793"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.1988.tb01053.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0275-5408(88)90175-5","article-title":"Fluctuations of intraocular pressure with sleep. 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