{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:41:49Z","timestamp":1785768109930,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To present the results of a 30\u2010year prospective study in which eyelid basal cell carcinomas were treated with cryosurgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Basal cell carcinomas with well\u2010defined borders on the eyelids or medial canthus, diagnosed by punch biopsy, were included. Cryosurgery was performed using liquid nitrogen sprayed into a cone circumscribing the tumours. The tumours were treated in a double freeze\u2010thaw cycles technique. The minimum thawing time of the frozen area outside the tumour margin was at least 60\u00a0seconds. During the first 20\u00a0years of the study, patients were re\u2010examined for up to 10\u00a0years. In the last 10\u00a0years of the study, most patients were followed up for 1\u00a0year, and if there was no visible scarring in the treated area at the 1\u2010year check\u2010up, follow\u2010ups were implemented at the patient's request following self\u2010assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 781 tumours in 768 patients were treated. The median age of the patients at treatment was 73\u00a0years, mean 70.9\u00a0years (range 22\u2013102\u00a0years). More women (58%) were treated than men. The median tumour size was 8\u00a0mm, mean 9.1\u00a0mm (range 2\u201325\u00a0mm). There were few side\u2010effects requiring intervention. Twelve patients underwent surgery due to ektropion during follow\u2010up. In 101 patients, treatment of the tumour resulted in conjunctival growth on the skin side, which required correcting operations in 28 patients. Three recurrences have occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cryosurgery is an effective treatment modality for eyelid basal cell carcinomas, resulting in few recurrences and good cosmetic and functional outcomes at a low cost.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12441","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T01:29:55Z","timestamp":1401758995000},"page":"787-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cryosurgery of eyelid basal cell carcinomas including 781 cases treated over 30\u00a0years"],"prefix":"10.1111","volume":"92","author":[{"given":"Gun","family":"Lindgren","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Sahlgrenska University Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Lark\u00f6","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska University Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.5858\/133.8.1256","article-title":"Introduction of the 7th edition eyelid carcinoma classification system from the American Joint Committee on Cancer\u2010International Union Against Cancer staging manual","volume":"133","author":"Ainbinder DJ","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1978.03910060099026"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81241-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.4.453"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06799.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(80)35207-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76088-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1997.tb00090.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1990.tb01916.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00952.x"},{"key":"e_1_2_6_12_1","first-page":"156","volume-title":"Basic and clinical sience course. Section 7. Orbit, eyelids, and lacrimal system","author":"Kersten RC","year":"2002"},{"key":"e_1_2_6_13_1","first-page":"566","article-title":"Evidence\u2010based review of the use of cryosurgery in treatment of basal cell carcinoma","volume":"29","author":"Kokoszka A","year":"2003","journal-title":"Dermatol Surg"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1978.tb00580.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30090.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80328-3"},{"key":"e_1_2_6_17_1","first-page":"513","article-title":"Characteristics and behavior of eyelid carcinoma (basal cell, squamous cell sebaceous gland, and malignant melanoma)","volume":"21","author":"Loeffler M","year":"1990","journal-title":"Ophthalmic Surg"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00445.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.1.85"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1989.tb03166.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170100260"},{"key":"e_1_2_6_22_1","first-page":"257","article-title":"Basal cell carcinoma on the eyelids: own experience","volume":"30","author":"Salomon J","year":"2004","journal-title":"Dermatologic Surg"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb12533.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08666.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.ds00064.x"},{"key":"e_1_2_6_26_1","first-page":"473","article-title":"Cancer of the eyelid\u2013a cryosurgical approach","volume":"4","author":"Zacarian SA","year":"1972","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70213-6"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12441","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:08:55Z","timestamp":1695499735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,2]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/aos.12441"],"URL":"https:\/\/doi.org\/10.1111\/aos.12441","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,2]]},"assertion":[{"value":"2013-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}