{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:48:37Z","timestamp":1776329317780,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,25]],"date-time":"2014-05-25T00:00:00Z","timestamp":1400976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Japanese Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","award":["22791659"],"award-info":[{"award-number":["22791659"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the short\u2010 and long\u2010term effects of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous\u2010deficient dry eye.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen eyes in 16 patients with mild or moderate aqueous\u2010deficient dry eye were treated with 3% diquafosol ophthalmic solution. Ocular higher\u2010order aberrations (<jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s) were measured with a wavefront sensor before and at 15\u00a0min after diquafosol instillation at the baseline visit and at 4\u00a0weeks after treatment initiation. Dry eye symptoms, tear break\u2010up time (<jats:styled-content style=\"fixed-case\">BUT<\/jats:styled-content>), corneal\/conjunctival fluorescein staining and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chirmer's test were also evaluated before and after treatment with diquafosol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with diquafosol ophthalmic solution significantly improved dry eye symptoms, corneal staining and <jats:styled-content style=\"fixed-case\">BUT<\/jats:styled-content>. Compared with mean total <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s at baseline (0.180\u00a0\u00b1\u00a00.06\u00a0\u03bcm), those at 4\u00a0weeks after treatment significantly decreased (0.148\u00a0\u00b1\u00a00.039\u00a0\u03bcm; p\u00a0=\u00a00.035), whereas those 15\u00a0min after diquafosol instillation at the baseline visit did not change significantly (0.170\u00a0\u00b1\u00a00.049\u00a0\u03bcm; p\u00a0=\u00a00.279).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although no significant change in <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s was observed as a short\u2010term effect of a single\u2010drop instillation of diquafosol, long\u2010term use of diquafosol to treat aqueous\u2010deficient dry eye reduced <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>s as well as improved corneal epithelial damage and tear film stability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12443","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T01:57:01Z","timestamp":1401069421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effect of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous\u2010deficient dry eye"],"prefix":"10.1111","volume":"92","author":[{"given":"Shizuka","family":"Koh","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"},{"name":"Research &amp; Development Division Rohto Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Oie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motokazu","family":"Tsujikawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12134"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1969.00990020012003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1998.0520"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8412"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0246"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.166"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00317-9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0018"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0762"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-013-0251-y"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12409"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12204"},{"key":"e_1_2_5_14_1","first-page":"221","article-title":"Report of the National Eye Institute\/industry workshop on clinical trials in dry eyes","volume":"21","author":"Lemp MA","year":"1995","journal-title":"CLAO J"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.2.C595"},{"key":"e_1_2_5_17_1","first-page":"S525","article-title":"Effect of tear film break\u2010up on higher order aberrations of the anterior cornea in normal, dry, and post\u2010LASIK eyes","volume":"21","author":"Lin YY","year":"2005","journal-title":"J Refract Surg"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.8.1053"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.04.010"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.02.041"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.12.044"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067042"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076887"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181b599bf"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.5.615"},{"key":"e_1_2_5_26_1","first-page":"181","article-title":"Definition and diagnosis of dry eye 2006","volume":"24","author":"Shimazaki J","year":"2007","journal-title":"Atarashii Ganka"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182930b1d"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301448"},{"key":"e_1_2_5_29_1","first-page":"181","article-title":"Stimulatory effect of diquafosol tetrasodium on tear fluid secretion in normal rabbits","volume":"24","author":"Takaoka\u2010Shichijo Y","year":"2011","journal-title":"Atarashii Ganka"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31821ea667"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12443","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:08:59Z","timestamp":1695499739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,25]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/aos.12443"],"URL":"https:\/\/doi.org\/10.1111\/aos.12443","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,25]]},"assertion":[{"value":"2014-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}