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In the present systematic review, we examined the need of follow\u2010up after posterior vitreous detachment (<jats:styled-content style=\"fixed-case\">PVD<\/jats:styled-content>) \u2013 diagnosed by slit\u2010lamp biomicroscopy or Goldmann 3\u2010mirror examination \u2013 with regard to retinal breaks as well as the indication of prophylactic treatment in asymptomatic and symptomatic breaks. A total of 2941 publications were identified with PubMed and Medline searches. Two manual search strategies were used for papers in English published before 2012. Four levels of screening identified 13 studies suitable for inclusion in this systematic review. No meta\u2010analysis was conducted as no data suitable for statistical analysis were identified. In total, the initial examination after symptomatic <jats:styled-content style=\"fixed-case\">PVD<\/jats:styled-content> identified 85\u201395% of subsequent retinal breaks. Additional retinal breaks were only revealed at follow\u2010up in patients where a full retinal examination was compromised at presentation by, for example, vitreous haemorrhage. Asymptomatic and symptomatic retinal breaks progressed to rhegmatogenous retinal detachment (<jats:styled-content style=\"fixed-case\">RRD<\/jats:styled-content>) in 0\u201313.8% and 35\u201347% of cases, respectively. The cumulated incidence of <jats:styled-content style=\"fixed-case\">RRD<\/jats:styled-content> despite prophylactic treatment was 2.1\u20138.8%. The findings in this review suggest that follow\u2010up after symptomatic <jats:styled-content style=\"fixed-case\">PVD<\/jats:styled-content> is only necessary in cases of incomplete retinal examination at presentation. Prophylactic treatment of symptomatic retinal breaks must be considered, whereas no unequivocal conclusion could be reached with regard to prophylactic treatment of asymptomatic retinal breaks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12447","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T03:41:01Z","timestamp":1400816461000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Prophylactic treatment of retinal breaks \u2013 a systematic review"],"prefix":"10.1111","volume":"93","author":[{"given":"S\u00f8ren","family":"Blindb\u00e6k","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Grauslund","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital Odense 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