{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T19:16:27Z","timestamp":1721762187788},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,13]],"date-time":"2014-07-13T00:00:00Z","timestamp":1405209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Peking University Peoples Hospital Research and Development Funds","award":["RDC2011-23"],"award-info":[{"award-number":["RDC2011-23"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the expression levels of cytokines, including growth factors, inflammatory cytokines, and cell migration associated factors on the iris from subjects with neovascular glaucoma (<jats:styled-content style=\"fixed-case\">NVG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After receiving formal consent from 12 subjects with <jats:styled-content style=\"fixed-case\">NVG<\/jats:styled-content> secondary to proliferative diabetic retinopathy and 12 subjects with primary open angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>), trabeculectomy was performed and iris specimens were collected during the surgery. Each subject with <jats:styled-content style=\"fixed-case\">NVG<\/jats:styled-content> received intravitreal injection of bevacizumab 1\u00a0week prior to the surgery. The m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> level of vascular endothelial growth factor, basic fibroblastic growth factor, placental\u2010induced growth factor, interleukin\u20102, interleukin 6, tumour necrosis factor \u03b1, intercellular adhesion molecule 1 (<jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101) and integrin subunit \u03b1<jats:sub>V<\/jats:sub> were determined by real\u2010time polymerase chain reaction. The m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> levels were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> levels of all inflammatory cytokines and integrin subunit \u03b1<jats:sub>V<\/jats:sub> were significantly increased in the <jats:styled-content style=\"fixed-case\">NVG<\/jats:styled-content> group compared with <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> controls. However, the m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> level of growth factors and <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 did not show any difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inflammatory process maybe an important cause of iris neovascularization in subjects with <jats:styled-content style=\"fixed-case\">NVG<\/jats:styled-content> in addition to growth factors alone. Further studies should focus on the effect of growth factors in different phases in the pathogenesis of <jats:styled-content style=\"fixed-case\">NVG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12510","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T16:02:31Z","timestamp":1405440151000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Expression of cytokines on the iris of patients with neovascular glaucoma"],"prefix":"10.1111","volume":"93","author":[{"given":"Xian\u2010ru","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Key Laboratory of Vision Loss and Restoration Ministry of Education Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases People's Hospital Peking University Beijing 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