{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:04:57Z","timestamp":1761807897486},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To compare the frequency of rejection and graft failure after Descemet's stripping automated endothelial keratoplasty (DSAEK<\/jats:styled-content>) and penetrating keratoplasty (PK<\/jats:styled-content>) for secondary endothelial failure.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010eight eyes undergoing DSAEK<\/jats:styled-content> from 2006 to 2013 and 80 eyes undergoing PK<\/jats:styled-content> from 1998 to 2013 were included. Indications were endothelial failure due to pseudophakic bullous keratopathy (82%), previous eye trauma (8%), uveitis (4%) or other causes (6%). Rejection episodes and graft failure were recorded, together with preoperative risk factors (glaucoma, neovascularization and active inflammation). Kaplan\u2013Meier survival curves with up to 4\u00a0years follow\u2010up were used to compare DSAEK<\/jats:styled-content> with PK<\/jats:styled-content>, as well as low\u2010risk with high\u2010risk eyes.<\/jats:p><\/jats:sec>Results<\/jats:title>During follow\u2010up, 15% of the PK<\/jats:styled-content>\u2010treated eyes and 4% of the DSAEK<\/jats:styled-content>\u2010treated eyes experienced rejection. Graft failure occurred in 8% of the PK<\/jats:styled-content>\u2010treated eyes and in 7% of the DSAEK<\/jats:styled-content>\u2010treated eyes. No significant differences were found in the rate of rejection (p\u00a0=\u00a00.11), graft failure (p\u00a0=\u00a00.29) or rejection\u2010related graft failure (p\u00a0=\u00a00.30) between DSAEK<\/jats:styled-content> and PK<\/jats:styled-content> in low\u2010risk eyes. In DSAEK<\/jats:styled-content>, high\u2010risk eyes (mainly with glaucoma) experienced significantly more rejection episodes (p\u00a0=\u00a00.01), graft failures (p\u00a0=\u00a00.04) and rejection\u2010related graft failures (p\u00a0=\u00a00.04) compared with low\u2010risk eyes. No differences were seen between high\u2010risk and low\u2010risk PK<\/jats:styled-content>\u2010treated eyes (p\u00a0>\u00a00.40).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In the present, relatively small study, no differences in rejection rate or graft failure were found between DSAEK<\/jats:styled-content> and PK<\/jats:styled-content> in low\u2010risk eyes. However, glaucoma seems to increase the risk of graft complications after DSAEK<\/jats:styled-content> for secondary endothelial failure. Long\u2010term studies of larger samples sizes are needed to confirm this.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12518","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T05:01:53Z","timestamp":1407819713000},"page":"172-177","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Graft rejection and failure following endothelial keratoplasty (DSAEK<\/scp>) and penetrating keratoplasty for secondary endothelial failure"],"prefix":"10.1111","volume":"93","author":[{"given":"Iben B.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Ivarsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31812f66e5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.019"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.086272"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.174"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01492.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182687ff3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790308.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-004-1148-4"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.039"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.10.1383"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f8bcc"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.140038"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.07.036"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.08.018"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.004"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12116"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12518","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:40:25Z","timestamp":1695555625000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,12]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/aos.12518"],"URL":"https:\/\/doi.org\/10.1111\/aos.12518","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,12]]},"assertion":[{"value":"2014-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}