{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:14:46Z","timestamp":1773076486167,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective nation\u2010based study of Danish patients with ocular adnexal follicular lymphoma from January 1st 1980 through December 31st 2009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63\u00a0years (range: 42\u201396\u00a0years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma and six patients (25%) presented with an ocular adnexal relapse. The most frequently affected sites were the lacrimal gland (38%) and the orbit (33%). Thirteen patients (54%) presented with Ann Arbor stage <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> lymphoma, four (17%) had stage <jats:styled-content style=\"fixed-case\">IIE<\/jats:styled-content>, two patients (8%) stage <jats:styled-content style=\"fixed-case\">IIIE<\/jats:styled-content>, and five patients (21%) had stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> lymphoma. Radiotherapy was primarily used in patients with primary lymphoma and those with a stage <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IIE<\/jats:styled-content> relapse (82%), while stage <jats:styled-content style=\"fixed-case\">IIIE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> lymphomas most frequently received alkylating chemotherapy (67%). Complete remission was observed in 19 of the patients (79%), but of these 11(58%) had a relapse. The 10\u2010year overall survival for the entire cohort was 59%. The translocation t(14;18) was detected in 16 patients (16\/24, 76%). Recurrence was only observed in patients with the t(14;18) (p\u00a0=\u00a00.05, log\u2010rank).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ocular adnexal follicular lymphoma is more commonly found in elderly female patients. The lacrimal gland is relatively frequently involved. Radiotherapy is the treatment of choice for localized ocular adnexal follicular lymphoma providing a favourable prognosis for majority of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12525","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T03:46:11Z","timestamp":1407987971000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Follicular lymphoma of the ocular adnexal region: A nation\u2010based study"],"prefix":"10.1111","volume":"93","author":[{"given":"Peter K.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Pharmacology Eye Pathology Institute University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Ralfkiaer","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet University of Copenhagen Copenhagen 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