{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:22:54Z","timestamp":1777414974615,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chonnam National University Hospital Biomedical Research Institute","award":["CRI14030-1"],"award-info":[{"award-number":["CRI14030-1"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare various optic nerve head (<jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content>) parameters and peripapillary retinal nerve fibre layer (p<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>) thickness between megalopapilla cases and normal control using spectral domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty eyes with megalopapilla and 80 normal control eyes of totally 130 children between the ages of 6 and 15 were examined using <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>. Optic nerve head parameters including disc diameter, cup\u2010to\u2010disc ratio, disc area, cup area, rim area, cup volume and rim volume, and p<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness were analysed and compared between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Megalopapilla group presented larger optic disc diameter, disc and cup area, cup\u2010to\u2010disc and cup\u2010to\u2010disc area ratio, when compared with normal control group. However, there is no difference in rim area (p\u00a0=\u00a00.25) and rim volume (p\u00a0=\u00a00.48) between the two groups. Average p<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness was higher in the megalopapilla group (p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rim area, rim volume and p<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>, which reflect the number of retinal nerve fibres, were preserved in children with megalopapilla. Various <jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content> parameters obtained with <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> may be useful in the differential diagnosis of megalopapilla in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12545","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T02:21:10Z","timestamp":1409624470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Megalopapilla in children: a spectral domain optical coherence tomography analysis"],"prefix":"10.1111","volume":"93","author":[{"given":"Hyo Seok","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chonnam National University Medical School and Hospital Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang 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