{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:39Z","timestamp":1788872439292,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003406","name":"Tekes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003406","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n Chronic conjunctival inflammation, caused by various reasons, for example long\u2010term use of topical drugs and\/or their preservatives, affects the outcome of glaucoma surgery by interfering with wound healing. Matrix metalloproteinases (\n MMP<\/jats:styled-content>\n s) remodel extracellular matrix (\n ECM<\/jats:styled-content>\n ) and are involved in the wound healing process. This study was designed to evaluate the conjunctival expression of\n MMP<\/jats:styled-content>\n s and their tissue inhibitors (\n TIMP<\/jats:styled-content>\n s) in the normal eye, primary open\u2010angle glaucoma (\n POAG<\/jats:styled-content>\n ) and exfoliation glaucoma (ExG) and whether there is an association between staining intensities and deep sclerectomy outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Immunohistochemical procedures were performed on conjunctival samples which were obtained from\n POAG<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u00a0=\u00a011) and ExG (\n n<\/jats:italic>\n \u00a0=\u00a014) patients as well as normal (\n n<\/jats:italic>\n \u00a0=\u00a07) subjects. Antibodies against\n MMP<\/jats:styled-content>\n s (\n MMP<\/jats:styled-content>\n \u20101, \u20102, \u20103 and \u20109) and\n TIMP<\/jats:styled-content>\n s (\n TIMP<\/jats:styled-content>\n \u20101, \u20102 and \u20103) were used.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In conjunctival stroma, expression levels of\n MMP<\/jats:styled-content>\n \u20102 (p\u00a0=\u00a00.047),\n MMP<\/jats:styled-content>\n \u20103 (p\u00a0=\u00a00.009),\n MMP<\/jats:styled-content>\n \u20109 (p\u00a0<\u00a00.001),\n TIMP<\/jats:styled-content>\n \u20101 (p\u00a0=\u00a00.003),\n TIMP<\/jats:styled-content>\n \u20102 (p\u00a0<\u00a00.001) and\n TIMP<\/jats:styled-content>\n \u20103 (p\u00a0<\u00a00.001) in ExG and\n MMP<\/jats:styled-content>\n \u20109 (p\u00a0=\u00a00.008),\n TIMP<\/jats:styled-content>\n \u20102 (p\u00a0=\u00a00.02) and\n TIMP<\/jats:styled-content>\n \u20103 (p\u00a0=\u00a00.002) in\n POAG<\/jats:styled-content>\n were significantly increased compared to control. We further found correlations between expression of\n MMP<\/jats:styled-content>\n \u20101 and\n MMP<\/jats:styled-content>\n \u20103 and the length of pilocarpine treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The expression of\n MMP<\/jats:styled-content>\n s and\n TIMP<\/jats:styled-content>\n s is increased in the conjunctiva of\n POAG<\/jats:styled-content>\n and ExG patients having a long history of topical antiglaucoma drops. Antiglaucoma agents and\/or their preservatives alter the remodelling balance of\n ECM<\/jats:styled-content>\n in conjunctiva of\n POAG<\/jats:styled-content>\n and ExG eyes. The balance between\n MMP<\/jats:styled-content>\n s and\n TIMP<\/jats:styled-content>\n s may play a crucial role in the conjunctival wound healing process and the outcome of glaucoma surgery.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.12550","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T22:41:18Z","timestamp":1413240078000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Conjunctival matrix metalloproteinases and their inhibitors in glaucoma patients"],"prefix":"10.1111","volume":"93","author":[{"given":"Minna","family":"Helin\u2010Toiviainen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"R\u00f6nkk\u00f6","sequence":"additional","affiliation":[{"name":"School of 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