{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:49:27Z","timestamp":1790196567525,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,2]],"date-time":"2014-11-02T00:00:00Z","timestamp":1414886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate serial changes in the bleb wall using anterior segment optical coherence tomography (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) in patients who had undergone Ahmed glaucoma valve (<jats:styled-content style=\"fixed-case\">AGV<\/jats:styled-content>) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 52 patients who had undergone <jats:styled-content style=\"fixed-case\">AGV<\/jats:styled-content> implantation were enrolled. Reflectivity and mean thickness of the bleb wall were examined using <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> at 1\u00a0day, 1\u00a0week, 1\u00a0month, 3\u00a0months and 6\u00a0months postoperatively. Intra\u2010ocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) and the number of glaucoma medications were evaluated. The hypertensive phase was defined as <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> &gt;21\u00a0mmHg during the first 3\u00a0months after surgery. Patients were divided into two groups: hypertensive and non\u2010hypertensive groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following <jats:styled-content style=\"fixed-case\">AGV<\/jats:styled-content> implantation, <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> decreased at each time\u2010point during postoperative follow\u2010up (p value\u00a0&lt;\u00a00.001, all) with a peak in the first month. Mean bleb wall thickness showed a U\u2010shaped curve postoperatively, being thinnest 1\u00a0month after the operation. Reflectivity showed an inverted U\u2010shaped curve postoperatively, being brightest 1\u00a0month after the operation. A hypertensive phase was observed in 44 patients (84.6%). The bleb wall was significantly more reflective (130.67\u00a0\u00b1\u00a027.00 versus 106.57\u00a0\u00b1\u00a010.35; p<jats:italic>\u00a0<\/jats:italic>=\u00a00.044) in the hypertensive group than in non\u2010hypertensive group 1\u00a0month postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypertensive phase peaked at 1\u00a0month after aqueous shunt surgery. At that time, the bleb wall had the highest reflectivity. The unique <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> pattern after tube surgery is related to fibrosis of the bleb wall qualitatively. Specific modulation of wound healing may be the target for attempts to decrease the development of hypertensive phase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12571","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T02:14:07Z","timestamp":1414980847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Serial changes in the bleb wall after glaucoma drainage implant surgery: characteristics during the hypertensive phase"],"prefix":"10.1111","volume":"93","author":[{"given":"Kyoung In","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Seoul St. Mary's 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