{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:18:42Z","timestamp":1791962322589,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY001792, EY017918"],"award-info":[{"award-number":["EY001792, EY017918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine alterations in bulbar conjunctival microvascular haemodynamics in sickle cell retinopathy (<jats:styled-content style=\"fixed-case\">SCR<\/jats:styled-content>) subjects with focal macular thinning (<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Conjunctival microcirculation imaging and spectral domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) were performed in 22 subjects (eyes) diagnosed with<jats:styled-content style=\"fixed-case\">SCR<\/jats:styled-content>. Based on evaluation of<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>retinal thickness maps, eyes were assigned to one of the two groups: with or without<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>. Conjunctival venular diameter and axial blood velocity were measured in multiple venules in each eye by customized image analysis algorithms. Measurements were then categorized into two vessel size groups (vessel size 1 and 2) and compared between<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>groups. A Pearson correlation coefficient was computed to assess the relationship between retinal thickness and axial blood velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age, haematocrit, sickle cell haemoglobin type and median retinopathy score were not significantly different between the two groups (p\u00a0\u2265\u00a00.1). Retinal thickness in parafoveal and perifoveal temporal subfields was significantly lower in eyes with<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>as compared to eyes without<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>(p\u00a0\u2264\u00a00.04). There was a significant effect of<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>on axial blood velocity (p\u00a0=\u00a00.04), while the effect of vessel size was not significant (p\u00a0=\u00a00.4). In vessel size 1, axial blood velocity was lower in eyes with<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>than in eyes without<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>(p\u00a0=\u00a00.03), while in vessel size 2, there was no statistically significant difference between<jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>groups (p\u00a0=\u00a00.1). In vessel size 1, there was a significant positive correlation between axial blood velocity and retinal thickness in the perifoveal (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.48, p\u00a0=\u00a00.02) and parafoveal (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.43, p\u00a0=\u00a00.04) temporal subfields.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conjunctival axial blood velocity in small venules is reduced in<jats:styled-content style=\"fixed-case\">SCR<\/jats:styled-content>subjects with focal macular thinning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12593","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T08:27:55Z","timestamp":1417076875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Conjunctival microvascular haemodynamics in sickle cell 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