{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:54:28Z","timestamp":1758120868854},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To analyse the influence of corneal cross\u2010linking (<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>) with ultraviolet\u2010A (UV\u2010A) and riboflavin on drug permeability in human subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Keratoconus patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a023; mean age 26.9\u00a0\u00b1\u00a05.8\u00a0years) undergoing a standard <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> procedure with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A (5.4\u00a0J\/cm<jats:sup>2<\/jats:sup>, 30\u00a0min) and riboflavin in one eye were included in the study. The pupillary diameter, measured before and every 3\u00a0min for 30\u00a0min after the topical application of one drop of 2% pilocarpine, was used as an indirect measure of the corneal permeability. The pupillary diameter was measured with an infrared pupillometer device before (baseline) and 4\u00a0months after <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to pilocarpine application, no significant difference in the pupillary diameter was detected before <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> and 4\u00a0months later. The mean decrease in the pupillary diameter after the application of pilocarpine was similar at baseline and the 4\u2010month follow\u2010up visit: mean decreases of 3.9 and 3.7\u00a0mm were observed 30\u00a0min after pilocarpine application, respectively (p\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant influence of <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> on the corneal penetration of topically applied pilocarpine was observed in this clinical study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12595","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T11:09:08Z","timestamp":1416654548000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of corneal cross\u2010linking on topical drug penetration in humans"],"prefix":"10.1111","volume":"93","author":[{"given":"Christoph","family":"Tappeiner","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Inselspital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Tschopp","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Inselspital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaspar","family":"Schuerch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Inselspital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice E.","family":"Frueh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Inselspital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.03.016"},{"key":"e_1_2_5_3_1","unstructured":"BearJ&BachmatY(1967):A generalized theory on hydrodynamic dispersion in porous media. 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