{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:25:12Z","timestamp":1790007912223,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Biomarin Europe Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The mucopolysaccharidoses (<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>) are a group of rare lysosomal storage disorders, characterized by the accumulation of glycosaminoglycans within multiple organ systems including the eye. This study aimed to determine the prevalence of glaucoma in patients with <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>, as well as the characteristics, diagnosis and management of patients with <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> and glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre retrospective case\u2010note review was carried out by ophthalmologists from four tertiary referral centres to identify patients with <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> who had been treated for glaucoma. Clinical ophthalmological data were collected using standardized data collection forms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen patients were identified (27 eyes) of 294 patients with <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>. The prevalence of glaucoma ranged from 2.1% to 12.5%. The median age at diagnosis of glaucoma was 8\u00a0years. Diagnostic evaluation of glaucoma was incomplete in many patients: intraocular pressure was documented in all eyes, but optic disc appearance was only assessed in 67%, central corneal thickness in 26%, visual fields in 19% and iridocorneal angle in 15%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> need regular assessment for possible glaucoma including during childhood. Multiple factors contribute to the challenges of assessment, diagnosis and monitoring of glaucoma in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12607","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T10:07:51Z","timestamp":1424167671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Assessment and diagnosis of suspected glaucoma in patients with mucopolysaccharidosis"],"prefix":"10.1111","volume":"93","author":[{"given":"Jane","family":"Ashworth","sequence":"first","affiliation":[{"name":"Manchester Royal Eye Hospital Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maree","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Children's Hospital at Westmead Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Pitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Centre Johannes Gutenberg University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azura","family":"Ramlee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Selayang Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.281"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701921"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.74.6.382"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73311-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2007.04.003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301189"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02280.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02085.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.179937"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.11.022"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.532"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.05.003"},{"key":"e_1_2_5_14_1","first-page":"286","article-title":"Mucopolysaccharidosis type I, Hurler\u2010Scheie phenotype with ocular involvement. 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