{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:09:02Z","timestamp":1792188542003,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T00:00:00Z","timestamp":1419724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371008"],"award-info":[{"award-number":["81371008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong province","doi-asserted-by":"crossref","award":["No. 2012B031800353"],"award-info":[{"award-number":["No. 2012B031800353"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n To compare the choroidal thickness (\n CT<\/jats:styled-content>\n ) in eyes with moderate and severe primary angle\u2010closure glaucoma (\n PACG<\/jats:styled-content>\n ) with the eyes of healthy controls.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifty\u2010nine patients (59 eyes) with\n PACG<\/jats:styled-content>\n and 56 age\u2010matched normal subjects underwent macular CT scanning using enhanced depth imaging\u2013optical coherence tomography. The subjects with\n PACG<\/jats:styled-content>\n were further classified as having moderate [\u221212\u00a0dB\u00a0\u2264\u00a0visual field mean deviation (VF\u2010MD)\u00a0\u2264\u00a0\u22126\u00a0dB] or severe (VF\u2010MD\u00a0<\u00a0\u221212\u00a0dB) glaucoma. The average\n CT<\/jats:styled-content>\n of the\n PACG<\/jats:styled-content>\n eyes at each location was compared to that of normal eyes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n CT<\/jats:styled-content>\n was significantly increased in moderate and severe\n PACG<\/jats:styled-content>\n eyes compared with the normal eyes at all nine macular locations, with the exception of 1 and 3\u00a0mm superior to the fovea. The mean\n CT<\/jats:styled-content>\n under the fovea was 292.0\u00a0\u00b1\u00a048.2\u00a0\n \u03bc<\/jats:italic>\n m in the moderate\n PACG<\/jats:styled-content>\n eyes, 277.1\u00a0\u00b1\u00a058.3\u00a0\n \u03bc<\/jats:italic>\n m in the severe\n PACG<\/jats:styled-content>\n eyes and 249.9\u00a0\u00b1\u00a072.1\u00a0\n \u03bc<\/jats:italic>\n m in the normal eyes, respectively. There were no significant differences between the macular\n CT<\/jats:styled-content>\n s in the eyes with moderate\n PACG<\/jats:styled-content>\n and those in severe\n PACG<\/jats:styled-content>\n eyes (all p\n \u00a0<\/jats:italic>\n >\n \u00a0<\/jats:italic>\n 0.05). Factors associated with a thinner choroid were ageing (p\n \u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001), female (p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.036) and increasing axial length (p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.021). Neither the\n VF<\/jats:styled-content>\n \u2010\n MD<\/jats:styled-content>\n nor pattern standard deviation was found to be associated with\n CT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The\n CT<\/jats:styled-content>\n is greater in patients with\n PACG<\/jats:styled-content>\n , but it does not differ between moderate and severe\n PACG<\/jats:styled-content>\n , suggesting a lack of relationship between\n CT<\/jats:styled-content>\n and the progression of glaucoma based on\n EDI<\/jats:styled-content>\n \u2010\n OCT<\/jats:styled-content>\n measurements.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.12616","type":"journal-article","created":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T21:31:34Z","timestamp":1419802294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Enhanced depth imaging\u2013optical coherence tomography of the choroid in moderate and severe primary angle\u2010closure glaucoma"],"prefix":"10.1111","volume":"93","author":[{"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"},{"name":"Department of Ophthalmology The 1st People's Hospital of Chenzhou City Chenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou 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