{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:58:47Z","timestamp":1773867527402,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe spontaneous corneal perforations in patients with atopic keratoconjunctivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of patients with atopic keratoconjunctivitis and spontaneous corneal perforation seen by the authors were reviewed. A literature search of corneal complications in atopic keratoconjunctivitis and predisposing factors for spontaneous corneal perforations in corneal ectasias was undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients with seven incidents of corneal perforation were identified and presented. Corneal thinning and keratoconus are observed at a higher rate in patients with atopic keratoconjunctivitis, and severe ocular allergy has been reported as a risk factor for corneal hydrops.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atopic keratoconjunctivitis appears to be a risk factor for spontaneous sterile corneal perforation. Corneal thinning and keratoconus in addition to inflammatory changes of the cornea in these patients probably predispose to the corneal melt in these perforations. A close observation of the fellow eye of affected patients is important and systemic immunosuppressive therapy should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12617","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T12:21:48Z","timestamp":1423830108000},"page":"383-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review"],"prefix":"10.1111","volume":"93","author":[{"given":"Emma","family":"Nivenius","sequence":"first","affiliation":[{"name":"Division of Ophthalmology and Vision Department of Clinical Neuroscience Karolinska Institutet St. Erik's Eye Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Montan","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology and Vision Department of Clinical Neuroscience Karolinska Institutet St. Erik's Eye Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30015-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)00792-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.63070"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200303000-00019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318172fbb1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02369.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.8.834"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30867-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.02.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32677-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31828f0e1e"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067211002000506"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ICL.0000103173.89427.74"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(06)80071-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32477-6"},{"key":"e_1_2_6_17_1","first-page":"21","article-title":"Ocular complications of atopic dermatitis","volume":"19","author":"Garrity JA","year":"1983","journal-title":"Can J Ophthalmol"},{"key":"e_1_2_6_18_1","first-page":"991","article-title":"Keratoconus and atopic diseases","volume":"10","author":"Gasset AR","year":"1978","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_6_19_1","first-page":"174","article-title":"Spontaneous corneal hydrops and perforation in pellucid marginal degeneration; a case report","volume":"4","author":"Gharebaghi D","year":"2009","journal-title":"J Ophthalmic Vis Res"},{"key":"e_1_2_6_20_1","first-page":"187","article-title":"Acute hydrops in the corneal ectasias: associated factors and outcomes","volume":"97","author":"Grewal S","year":"1999","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.73.10.816"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000151547.08113.d1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30144-4"},{"key":"e_1_2_6_24_1","first-page":"598","article-title":"Four cases of corneal perforation in patients with chronic graft\u2010versus\u2010host disease","volume":"17","author":"Inagaki E","year":"2011","journal-title":"Mol Vis"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080120033016"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273940903572538"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180de1e04"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.71.3.207"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126379"},{"key":"e_1_2_6_30_1","first-page":"230","article-title":"Keratoconus with spontaneous perforation of the cornea","volume":"22","author":"Lahoud S","year":"1987","journal-title":"Can J Ophthalmol"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181e2efcf"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e318164771b"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0766"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199703000-00018"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000208820.32614.00"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2003.tb03082.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31816ed516"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181ac4faa"},{"key":"e_1_2_6_39_1","first-page":"574","article-title":"Cornea fistula","volume":"18","author":"Musco PS","year":"1987","journal-title":"Ophthalmic Surg"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00028-0"},{"key":"e_1_2_6_41_1","first-page":"186","article-title":"Spontaneous corneal perforation in pellucid marginal degeneration","volume":"24","author":"Orlin SE","year":"1998","journal-title":"CLAO J"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2125"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)94017-9"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30755-5"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199110010-00019"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31818cd077"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76533-X"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.1.120"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000240091.11854.14"},{"key":"e_1_2_6_50_1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/ICO.0b013e3180398e93","article-title":"Corneal perforation associated with pellucid marginal degeneration and treatment with crescentic lamellar keratoplasty: two case reports","volume":"26","author":"Symes RJ","year":"2007","journal-title":"Cornea"},{"key":"e_1_2_6_51_1","first-page":"88","article-title":"Ocular complications of vernal keratoconjunctivitis","volume":"34","author":"Tabbara KF","year":"1999","journal-title":"Can J Ophthalmol"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00664-3"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12348-011-0048-4"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32322-4"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31110-9"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:16:17Z","timestamp":1695550577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,12]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/aos.12617"],"URL":"https:\/\/doi.org\/10.1111\/aos.12617","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,12]]},"assertion":[{"value":"2014-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}