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It predominantly affects males over their forties. It has many other names such as Bietti's band\u2010shaped nodular dystrophy, Labrador keratopathy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degeneration, elastoid degeneration and keratinoid corneal degeneration.\n                    <jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>\n                    is characterized by the haziness and opalescence of the cornea's most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman's membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of\n                    <jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>\n                    are unknown, but they are possibly multifactorial. The only treatment in\n                    <jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>\n                    advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on\n                    <jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>\n                    's pathogenesis which will open the prospect for new therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1111\/aos.12628","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T02:57:31Z","timestamp":1422413851000},"page":"496-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Climatic droplet keratopathy: an old disease in new clothes"],"prefix":"10.1111","volume":"93","author":[{"given":"Horacio M.","family":"Serra","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Faculty of Chemical Sciences CIBICI Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha 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