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They all underwent visual field (<jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>) tests (Humphrey 24\u20102) and scans using a Fourier\u2010domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) device (<jats:styled-content style=\"fixed-case\">RTV<\/jats:styled-content>ue\u2010100) at the beginning of the study and 2\u00a0years later. Mean deviation (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>), standard pattern deviation (<jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>), peripapillary retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>) and macular ganglion cell complex (<jats:styled-content style=\"fixed-case\">GCC<\/jats:styled-content>) parameters were considered for the analysis. Patients were also classified according to <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> deterioration (fast deterioration vs. slow deterioration).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Visual field global indices, peripapillary <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness and macular <jats:styled-content style=\"fixed-case\">GCC<\/jats:styled-content> thickness showed no differences among the groups at the beginning and end of the follow\u2010up. Besides all the comparisons among groups for differences before and after the follow\u2010up of the <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PSD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RNFL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GCC<\/jats:styled-content> parameters were also non\u2010significant. The proportions of patients according to <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> deterioration were similar among the groups and subgroups (p\u00a0&gt;\u00a00.05 for all the comparisons).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral antioxidant supplementation with or without <jats:italic>\u03c9<\/jats:italic>\u20103 fatty acids does not appear useful as an adjuvant treatment of mild\/moderate <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> in the short term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12629","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T03:09:17Z","timestamp":1419822557000},"page":"546-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["A two\u2010year follow\u2010up of oral antioxidant supplementation in primary open\u2010angle glaucoma: an open\u2010label, randomized, controlled trial"],"prefix":"10.1111","volume":"93","author":[{"given":"Jose Javier","family":"Garcia\u2010Medina","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Huercal Overa Hospital Almeria Spain"},{"name":"Department of Ophthalmology Reina Sofia University Hospital Murcia Spain"},{"name":"Department of Ophthalmology and Optometry School of Medicine University of Murcia Murcia Spain"},{"name":"Ophthalmology Research Unit \u201cSantiago Grisolia\u201d Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Garcia\u2010Medina","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Torrecardenas Hospital Almeria Spain"},{"name":"Head of the Andalusian Ophthalmic Research Group (GIAO) Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garrido\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Eastern Andalusian Biosanitary Research Foundation \u201cAlejandro Otero\u201d (FIBAO) Torrecardenas Hospital Almeria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Galvan\u2010Espinosa","sequence":"additional","affiliation":[{"name":"Eastern Andalusian Biosanitary Research Foundation \u201cAlejandro Otero\u201d (FIBAO) Torrecardenas Hospital Almeria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Garcia\u2010Maturana","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Zanon\u2010Moreno","sequence":"additional","affiliation":[{"name":"Genetic and Molecular Epidemiology Unit Department of Preventive Medicine &amp; Public Health School of Medicine University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dolores","family":"Pinazo\u2010Duran","sequence":"additional","affiliation":[{"name":"Ophthalmology Research Unit \u201cSantiago Grisolia\u201d Valencia Spain"},{"name":"Department of Ophthalmology School of Medicine University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4997"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000212Y.0000000033"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.12.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00658-3"},{"key":"e_1_2_5_6_1","volume-title":"HFA II\u2010i User Manual","author":"Carl Zeiss Meditec","year":"2005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.09.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.01.022"},{"key":"e_1_2_5_9_1","unstructured":"ForchheimerI deMoraesCG TengCC FolgarF TelloC RitchR&LiebmannJM(2010).Intraocular Pressure Baseline Visual Field (V) Mean deviation (MD) and glaucoma progression. 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