{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:09:04Z","timestamp":1792188544735,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Glaukooma Tukis\u00c3\u00a4\u00c3\u00a4ti\u00c3\u00b6 Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To investigate and compare functioning versus non\u2010functioning glaucoma drainage implant (GDI<\/jats:styled-content>) capsules for selective markers of extracellular matrix degradation and vascularity.<\/jats:p><\/jats:sec>Methods<\/jats:title>In three samples of both functioning and non\u2010functioning blebs, immunohistochemistry was used to determine the expression of MMP<\/jats:styled-content>\u20101, MMP<\/jats:styled-content>\u20102, MMP<\/jats:styled-content>\u20103, MMP<\/jats:styled-content>\u20109, TIMP<\/jats:styled-content>\u20101, TIMP<\/jats:styled-content>\u20102, TIMP<\/jats:styled-content>\u20103 and CD<\/jats:styled-content>31. A non\u2010functioning bleb was defined as IOP<\/jats:styled-content> >21\u00a0mmHg or <20% reduction in IOP<\/jats:styled-content> from baseline with maximal tolerated medication. The samples were classified into five grades based on immunostaining: no staining, no significant staining, mild, moderate or marked staining.<\/jats:p><\/jats:sec>Results<\/jats:title>Expression of MMP<\/jats:styled-content>\u20101, MMP<\/jats:styled-content>\u20102 and MMP<\/jats:styled-content>\u20103 was mostly low in both functioning and non\u2010functioning blebs. However, immunostaining of MMP<\/jats:styled-content>\u20109 was marked in samples taken from functioning GDI<\/jats:styled-content>s and correlated with the presence of vascular profiles in the luminal bleb. CD<\/jats:styled-content>31 immunoreactivity was more intense in the outer layers of the bleb than in the inner layers. In non\u2010functioning blebs, immunoreactivity for TIMP<\/jats:styled-content>\u20103 was significant through the whole bleb wall, but only mild in the inner zone of functioning blebs. TIMP<\/jats:styled-content>\u20101 and TIMP<\/jats:styled-content>\u20102 were barely detectable.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Staining of TIMP<\/jats:styled-content>\u20103 was seen to be lower in the vicinity of the small blood vessels. In avascular bleb wall, increased expression of TIMP<\/jats:styled-content>\u20103 suggests its potential role in the inhibition of angiogenesis as reported previously in\u00a0vivo<\/jats:italic>. The abundance of MMP<\/jats:styled-content>\u20109 in bleb capsule wall of relatively old patients might lead to weakened bleb capsule wall architecture and increasing filtration of aqueous humour through the capsule, which are reflected in a lower IOP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12654","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T02:33:58Z","timestamp":1421289238000},"page":"450-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Matrix metalloproteinases (MMP\u20101, MMP\u20102, MMP\u20103 and MMP\u20109, and TIMP\u20101, TIMP\u20102 and\u00a0TIMP\u20103) and markers for vascularization in\u00a0functioning and non\u2010functioning bleb capsules of\u00a0glaucoma drainage implants"],"prefix":"10.1111","volume":"93","author":[{"given":"Juha","family":"V\u00e4lim\u00e4ki","sequence":"first","affiliation":[{"name":"Department of 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