{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:37:21Z","timestamp":1787503041032,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guandong Natural Science Foundation","doi-asserted-by":"publisher","award":["S2013040016405"],"award-info":[{"award-number":["S2013040016405"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371008"],"award-info":[{"award-number":["81371008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n To compare the concentrations of chemokine (C\u2010C motif) ligand 2 (\n CCL<\/jats:styled-content>\n 2) and chemokine (C\u2010C motif) ligand 7 (\n CCL<\/jats:styled-content>\n 7) in aqueous humour of eyes with acute primary angle\u2010closure (\n APAC<\/jats:styled-content>\n ), primary angle\u2010closure glaucoma (\n PACG<\/jats:styled-content>\n ) or with age\u2010related cataract.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The prospective investigation included a study group of 56 patients (24 patients with\n APAC<\/jats:styled-content>\n ; 32 patients with\n PACG<\/jats:styled-content>\n ) undergoing glaucoma surgery and a control group of 21 patients undergoing routine cataract surgery. The interval between glaucoma attack and trabeculectomy was 19.4\u00a0\u00b1\u00a09.8\u00a0days.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The concentrations of\n CCL<\/jats:styled-content>\n 2 (3037\u00a0\u00b1\u00a0501 versus 1127\u00a0\u00b1\u00a0141\u00a0pg\/ml; p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.003) and\n CCL<\/jats:styled-content>\n 7 (10.5\u00a0\u00b1\u00a02.4 versus 2.8\u00a0\u00b1\u00a00.4\u00a0pg\/ml; p\n \u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001) were significantly higher in the\n APAC<\/jats:styled-content>\n group than in the\n PACG<\/jats:styled-content>\n group, while the concentrations of both cytokines did not differ significantly between the\n PACG<\/jats:styled-content>\n group and the control group (\n CCL<\/jats:styled-content>\n 2: 1190\u00a0\u00b1\u00a098\u00a0pg\/ml; p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.10;\n CCL<\/jats:styled-content>\n 7: 2.0\u00a0\u00b1\u00a00.6; p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.18). The concentrations of both cytokines were significantly and inversely correlated with the interval between the acute angle\u2010closure attack and surgery (\n CCL<\/jats:styled-content>\n 2: p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.02;\n \u03c1\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n \u22120.48;\n CCL<\/jats:styled-content>\n 7: p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.04;\n \u03c1\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n \u22120.42). Higher\n CCL<\/jats:styled-content>\n 2 concentrations were associated with higher prevalence of surgical failure (28.6% versus 7.1%; p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.036).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Concentrations of\n CCL<\/jats:styled-content>\n 2 and\n CCL<\/jats:styled-content>\n 7 as major inflammatory cytokines with potential influence on the risk of filtering surgery failure were significantly elevated after an acute glaucoma attack and decreased with longer interval to the attack. Trabeculectomy may have a lower risk of failure if performed later than earlier after an acute glaucoma attack, with lower\n CCL<\/jats:styled-content>\n 2 concentrations associated with better surgical outcome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.12696","type":"journal-article","created":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T20:46:59Z","timestamp":1425242819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chemokine (C\u2010C motif) ligand 2 and chemokine (C\u2010C motif) ligand 7 in angle\u2010closure glaucoma"],"prefix":"10.1111","volume":"94","author":[{"given":"Xinbo","family":"Gao","sequence":"first","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolin","family":"Du","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shida","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Li","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost 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