{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:47:07Z","timestamp":1792176427622,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T00:00:00Z","timestamp":1428019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n To evaluate the corneal sub\u2010basal nerve plexus in patients presenting with hypoesthesia following surgery for trigeminal neuralgia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Twenty\u2010one patients who had unilateral medically uncontrolled trigeminal neuralgia and underwent ipsilateral surgery from 2006 to 2012 were included. Of these, 10 had microvascular decompression (\n MVD<\/jats:styled-content>\n group) and 11 had balloon compression of the trigeminal ganglion (\n BC<\/jats:styled-content>\n group). Slit lamp examination, Cochet\u2013Bonnet aesthesiometery and\n in vivo<\/jats:italic>\n confocal microscopy were carried out on both eyes of each patient. Nerve density data were statistically analysed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Corneal sensations and sub\u2010basal nerve densities in\n MVD<\/jats:styled-content>\n group were normal and equal in both the operated and unoperated sides, indicating that there was no intra\u2010operative damage of the ophthalmic division of the trigeminal nerve (V1). However, those in\n BC<\/jats:styled-content>\n group, despite having significantly reduced corneal sensations on the operated side (p\u00a0=\u00a00.007), did not demonstrate any significant difference in their sub\u2010basal nerve densities (p\u00a0=\u00a00.477). No patient had any ocular symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study supports the hypothesis that complete ganglionic damage and\/or postganglionic damage of V1 results in corneal hypoesthesia and neurotrophic keratitis, but partial ganglionic or preganglionic damage would preserve trophic function despite hypoesthesia and not result in clinically significant symptoms or signs of neurotrophic keratitis. The trophic and sensory functions of V1 are therefore independent and can be dissociated by disease or injury.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.12697","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T15:54:15Z","timestamp":1428076455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Corneal hypoesthesia with normal sub\u2010basal nerve density following surgery for trigeminal neuralgia"],"prefix":"10.1111","volume":"94","author":[{"given":"Virinder K.","family":"Dhillon","sequence":"first","affiliation":[{"name":"Division of Clinical Neuroscience Academic Ophthalmology University of Nottingham England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Elalfy","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Academic Ophthalmology University of Nottingham England UK"},{"name":"The Research Institute of Ophthalmology Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhamed","family":"Al\u2010Aqaba","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Academic Ophthalmology University of Nottingham England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Academic Ophthalmology University of Nottingham England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nottingham University Hospitals Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harminder S.","family":"Dua","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Academic Ophthalmology University of Nottingham England 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