{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:59:13Z","timestamp":1757699953029},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2012R1A1A1038648"],"award-info":[{"award-number":["2012R1A1A1038648"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the macular thickness and volume change, and inflammatory cytokine levels after cataract surgery performed using two different sizes of incision (microincision versus small incision).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized, comparative clinical trial, 84 eyes with nuclear density from Grade 3\u20134 were randomly divided into two groups (microincision, 2.2\u00a0mm; and small incision, 2.75\u00a0mm). Forty\u2010two patients underwent phacoemulsification with microincision coaxial cataract surgery and 42 patients underwent phacoemulsification with small incision coaxial cataract surgery. Clinical measurements included preoperative, 1\u2010week, 1\u2010month and 2\u2010month postoperative best corrected visual acuity, central corneal thickness (<jats:styled-content style=\"fixed-case\">CCT<\/jats:styled-content>) and endothelial cell count. <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> were performed for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2 preoperatively and at 1\u00a0week postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage increase in <jats:styled-content style=\"fixed-case\">CCT<\/jats:styled-content> in the microincision group was significantly higher than that in the small incision group at 1\u00a0week after cataract surgery (p\u00a0=\u00a00.01). The increase in macular thickness in the microincision group was significantly higher than that in small incision group at 1\u00a0month after cataract operation (p\u00a0=\u00a00.04). Also, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2 concentrations and their expression ratio in the microincision group were significantly higher than those in the small incision group at 1\u00a0week after cataract surgery compared to the preoperative period (p\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Phacoemulsification with microincision coaxial cataract surgery may increase the macular thickness compared to phacoemulsification with small incision coaxial cataract surgery. Blood\u2013aqueous barrier breakdown may occur more frequently after microincision cataract surgery than after small incision cataract surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12716","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T19:58:40Z","timestamp":1428004720000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of macular thickness and inflammatory cytokine levels after microincision versus small incision coaxial cataract surgery"],"prefix":"10.1111","volume":"94","author":[{"given":"Ho Sik","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chuncheon Sacred Heart Hospital College of Medicine Hallym University Chuncheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye Jin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Science College of Medicine Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine Research College of Medicine Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; 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