{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:23:51Z","timestamp":1789161831088,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T00:00:00Z","timestamp":1428019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the outcomes of canaloplasty and trabeculectomy in open\u2010angle glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, randomized clinical trial included 62 patients who randomly received trabeculectomy (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) or canaloplasty (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) and were followed up prospectively for 2\u00a0years. Primary endpoint was complete (without medication) and qualified success (with or without medication) defined as an intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) of \u226418\u00a0mmHg (definition 1) or <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> \u226421\u00a0mmHg and \u226520% <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction (definition 2), <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> \u22655\u00a0mmHg, no vision loss and no further glaucoma surgery. Secondary endpoints were the absolute <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction, visual acuity, medication, complications and second surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surgical treatment significantly reduced <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> in both groups (p\u00a0&lt;\u00a00.001). Complete success was achieved in 74.2% and 39.1% (definition 1, p\u00a0=\u00a00.01), and 67.7% and 39.1% (definition 2, p\u00a0=\u00a00.04) after 2\u00a0years in the trabeculectomy and canaloplasty group, respectively. Mean absolute <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction was 10.8\u00a0\u00b1\u00a06.9\u00a0mmHg in the trabeculectomy and 9.3\u00a0\u00b1\u00a05.7\u00a0mmHg in the canaloplasty group after 2\u00a0years (p\u00a0=\u00a00.47). Mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was 11.5\u00a0\u00b1\u00a03.4\u00a0mmHg in the trabeculectomy and 14.4\u00a0\u00b1\u00a04.2\u00a0mmHg in the canaloplasty group after 2\u00a0years. Following trabeculectomy, complications were more frequent including hypotony (37.5%), choroidal detachment (12.5%) and elevated <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> (25.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Trabeculectomy is associated with a stronger <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction and less need for medication at the cost of a higher rate of complications. If target pressure is attainable by moderate <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction, canaloplasty may be considered for its relative ease of postoperative care and lack of complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12722","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T19:54:42Z","timestamp":1428090882000},"page":"753-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Trabeculectomy versus canaloplasty (<scp>TVC<\/scp> study) in the treatment of patients with open\u2010angle glaucoma: a prospective randomized clinical trial"],"prefix":"10.1111","volume":"93","author":[{"given":"Juliane","family":"Matlach","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of W\u00fcrzburg W\u00fcrzburg 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