{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:54:09Z","timestamp":1780469649040,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the interrelationship between the oxygen supply of the retina and its regulation with the severity of primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Central retinal artery (CRAE) and vein (CRVE) diameters and oxygen saturation of peripapillary retinal vessels in 41 patients suffering from POAG (64.1\u00a0\u00b1\u00a012.9 years) and 40 healthy volunteers (63.6\u00a0\u00b1\u00a014.1 years) were measured using the retinal vessel analyzer. All measures were taken before and during flicker light stimulation. The mean retinal nerve fiber layer thickness (RNFLT) was determined by OCT and the visual field mean defect (MD) was identified using perimetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In glaucoma patients, CRAE (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.48 p\u00a0=\u00a00.002) and CRVE (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.394 p\u00a0=\u00a00.014) at baseline were inversely related to MD, while arterial and venous oxygen saturation showed no significant dependence on the severity of the damage. However, the flicker light\u2010induced change in arterio\u2010venous difference in oxygen saturation was correlated with the MD (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.358 p\u00a0=\u00a00.027). The diameters of arteries and veins at baseline decreased with reduction of the mean RNFLT (arteries: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.718 p\u00a0&lt;\u00a00.001; veins: <jats:italic>r<\/jats:italic> = 0.685 p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vessel diameters showed a strong correlation with <jats:styled-content style=\"fixed-case\">RNFLT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. This, as well as the reduction of stimulation\u2010induced change in arterio\u2010venous oxygen saturation difference with visual field loss, may be explained by a reduction of the retinal metabolic demand with progressive loss of neuronal tissue in glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12727","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T03:38:50Z","timestamp":1429155530000},"page":"276-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Dependence of diameters and oxygen saturation of retinal vessels on visual field damage and age in primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"94","author":[{"given":"Lisa","family":"Ramm","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Jentsch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine","family":"Augsten","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,15]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Augenheilkunde","author":"Augustin AJ","year":"2007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.2.748"},{"key":"e_1_2_6_4_1","first-page":"2201","article-title":"False\u2010negative responses in glaucoma perimetry: indicators of patient performance or test reliability?","volume":"41","author":"Bengtsson B","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/692609"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.11.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(03)00064-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.9.735"},{"key":"e_1_2_6_9_1","volume-title":"Terminology and guidelines for glaucoma","author":"European\u00a0Glaucoma\u00a0Society","year":"2008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.04.055"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.08.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200408000-00013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5490"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9912"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1842-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302779"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2276-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2976032"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5537"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1753"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-1980-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90525-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182979e7b"},{"key":"e_1_2_6_24_1","first-page":"1604","article-title":"Parapapillary retinal vessel diameter in normal and glaucoma eyes. 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