{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:23:07Z","timestamp":1776694987702,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,12]],"date-time":"2015-04-12T00:00:00Z","timestamp":1428796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to evaluate the involvement of human papillomavirus in the pathogenesis of primary and recurrent pterygium in northern Israel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study examined 100 randomly chosen pterygium specimens with solar elastosis, from 100 patients who underwent pterygium surgery during 2012\u20132013 at the Emek Medical Center. All the specimens were analysed for evidence of human papillomavirus infection by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human papillomavirus was not detected in any of the 100 pterygia samples by immunohistochemistry. These used samples were taken from 100 patients with mean age of 51.5\u00a0years and a primary: recurrent ratio of 8.09:1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude from our study that human papillomavirus infection does not appear to be an important pathogenic factor of pterygium in Israel.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12729","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T03:35:41Z","timestamp":1428896141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of human papillomavirus in pterygium"],"prefix":"10.1111","volume":"94","author":[{"given":"Shirin","family":"Hamed\u2010Azzam","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Emek Medical Center Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Edison","sequence":"additional","affiliation":[{"name":"The Tissue Diagnostics and Cancer Research Institute Emek Medical Center Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Briscoe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Emek Medical Center Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abed","family":"Mukari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Emek Medical Center Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Elmalah","sequence":"additional","affiliation":[{"name":"The Tissue Diagnostics and Cancer Research Institute Emek Medical Center Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601743"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1438"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.8.1046"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12427"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70103-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.11.734"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199908000-00011"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1967.00980030487014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000149"},{"key":"e_1_2_5_11_1","first-page":"35","article-title":"Molecular genetic alterations and viral presence in ophthalmic pterygium","volume":"6","author":"Detorakis ET","year":"2000","journal-title":"Int J Mol Med"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200103000-00010"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.312"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.12.1593"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.7.782"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680903007162"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181afdb06"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.7.595"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.086314"},{"key":"e_1_2_5_20_1","first-page":"184","article-title":"Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia","volume":"33","author":"McDonnell JM","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.4.308"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(03)00196-X"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210901900201"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01372.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.7.864"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.4238\/vol7-4gmr528"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492006000400012"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02314.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.108829"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.176"},{"key":"e_1_2_5_31_1","first-page":"1092","article-title":"HPV infection and p53 inactivation in pterygium","volume":"15","author":"Tsai YY","year":"2009","journal-title":"Mol Vis"},{"key":"e_1_2_5_32_1","first-page":"24","article-title":"Human papillomavirus in pterygium","volume":"40","author":"Varinli S","year":"1994","journal-title":"Cent Afr J Med"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12729","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:38:40Z","timestamp":1695548320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,12]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/aos.12729"],"URL":"https:\/\/doi.org\/10.1111\/aos.12729","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,12]]},"assertion":[{"value":"2014-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}