{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T15:37:34Z","timestamp":1776526654709,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To quantify subjective visual metamorphopsia in newly diagnosed patients suffering from diabetic macular oedema (<jats:styled-content style=\"fixed-case\">DME<\/jats:styled-content>) and other macular abnormalities and to evaluate anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> treatment effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">DME<\/jats:styled-content>, subfoveal choroidal neovascularization (<jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>) secondary to age\u2010related macular degeneration (<jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>) or retinal venous occlusion (<jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>) were recruited. Metamorphopsia score (Mscore) was calculated using M\u2010Charts at baseline and at the end of a series of anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen eyes of 10 patients with <jats:styled-content style=\"fixed-case\">DME<\/jats:styled-content>, 14 eyes of 13 patients with <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> and five patients with <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> were included in this study. At baseline, positive Mscore was observed in 46.6% of eyes with <jats:styled-content style=\"fixed-case\">DME<\/jats:styled-content>, 50% of eyes with <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> and four of five eyes with <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>. Treatment led to a complete metamorphopsia reduction (Mscore\u00a0=\u00a00) in 71.4% of <jats:styled-content style=\"fixed-case\">DME<\/jats:styled-content> patients, 35.7% of <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content> and 0% of <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggest that the M\u2010charts may serve as an additional test for diagnosis and follow\u2010up, complementary to morphological evaluation by imaging, in diabetic patients facing their first anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12735","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T01:09:08Z","timestamp":1429578548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Quantifying metamorphopsia in patients with diabetic macular oedema and other macular abnormalities"],"prefix":"10.1111","volume":"93","author":[{"given":"Asaf","family":"Achiron","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Edith Wolfson Medical Center Holon Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oded","family":"Lagstein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Edith Wolfson Medical Center Holon Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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