{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:51:57Z","timestamp":1793404317991,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministero della Salute \u2018Finanziamento Ricerca Corrente (contributo per la ricerca intramurale)\u2019"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate choroidal abnormalities in paediatric patients with neurofibromatosis type 1 (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1) detected by near\u2010infrared reflectance (<jats:styled-content style=\"fixed-case\">NIR<\/jats:styled-content>) retinography in order to evaluate diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010eight paediatric patients with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1, diagnosed according to the National Institutes of Health (<jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content>) criteria, and 96 healthy control subjects matched for age were examined. Enrolled patients were under 16\u00a0years old. The presence of choroidal abnormalities was investigated by confocal scanning laser ophthalmoscopy. Main outcome measure was to evaluate diagnostic accuracy in paediatric patients compared with the <jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content> criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight patients with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 (41 female, 37 male; mean age 8.1\u00a0\u00b1\u00a03.5\u00a0years) were compared with 96 healthy control subjects (42 female, 54 male; mean age 8\u00a0\u00b1\u00a03\u00a0years). Choroidal abnormalities were observed in 54 (69.2%) of the patients with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1. As regards the fundus topographical distribution, choroidal abnormalities were more frequent at the posterior pole with a statistically significant correlation between patient age and the number of involved choroidal areas (Spearman <jats:italic>r<\/jats:italic>\u00a0=\u00a00.23; p\u00a0&lt;\u00a00.04). No choroidal abnormalities were present in the control group. Detection accuracy of choroidal nodules was 70%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Choroidal abnormalities appearing as bright patchy regions detected by <jats:styled-content style=\"fixed-case\">NIR<\/jats:styled-content> imaging occurred very frequently in paediatric patients affected by <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1. The present study appears to show that <jats:styled-content style=\"fixed-case\">NIR<\/jats:styled-content> used to detect choroidal involvement allows for elevated diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12750","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T16:49:13Z","timestamp":1432054153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Choroidal abnormalities in neurofibromatosis type 1 detected by near\u2010infrared reflectance imaging in paediatric population"],"prefix":"10.1111","volume":"93","author":[{"given":"Aldo","family":"Vagge","sequence":"first","affiliation":[{"name":"Eye Clinic DiNOGMI University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Camicione","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Giannina Gaslini Institute Genoa 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