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With the known microbicidal and corneal stiffening effects of ultraviolet irradiation and photoactivated riboflavin, it has recently been introduced for the management of infectious keratitis, especially for ulcers resistant to antimicrobial therapy or associated with corneal melting. Various authors have attempted to use <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> as an adjunctive, salvage or even as the sole treatment for infectious corneal ulcers. The aim of this review was to provide a summary of the clinical studies in the literature. It is worth noting that there is still no consensus on the treatment protocol of <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> against infectious keratitis. The disparities in outcome measures, treatment protocol and study design can confound the interpretation and hamper the generalization of the study results. Based on current evidence, the role of <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> in infectious keratitis remained unclear despite the reported success in some clinical cases. Further investigations are warranted concerning the efficacy and safety of treating infectious keratitis with <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/aos.12754","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T16:31:21Z","timestamp":1432053081000},"page":"689-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Corneal collagen cross\u2010linking for infectious keratitis: an update of clinical studies"],"prefix":"10.1111","volume":"93","author":[{"given":"Tommy C. 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