{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:13:48Z","timestamp":1791332028404,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The study was performed to analyse the retina of patients with Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) for morphological changes compared to healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) using spectral\u2010domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) and confocal scanning laser ophthalmoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 108 patients with idiopathic <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and 165 <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. All study participants underwent an ophthalmological examination to exclude ophthalmological disorder potentially interfering with the retinal analyses. Peripapillary retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>) thickness and macular thickness and volume were measured by a <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> device (Heidelberg Spectralis<jats:sup>\u00ae<\/jats:sup>). Stereometric parameters of the optic disc were acquired by Heidelberg Retina Tomograph (<jats:styled-content style=\"fixed-case\">HRT III<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness did not significantly differ between patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. The thickness of the central minimum and the centre of the macular area were significantly reduced in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, while the total macular volume did not significantly differ between the groups. Furthermore, we noted an inverse correlation between the central minimum thickness and the disease severity (assessed by the Hoehn and Yahr scale). <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> data showed no significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> device and the <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> measurements of the <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> did not prove to be a clinically valid diagnostic tool to distinguish eyes of patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. However, the macular region and especially the foveola (central minimum) with the highest density of photoreceptor cells seem to be more sensitive and might be potential biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12757","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T08:44:58Z","timestamp":1434012298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Detection of retinal changes in idiopathic Parkinson's disease using high\u2010resolution optical coherence tomography and heidelberg retina tomography"],"prefix":"10.1111","volume":"93","author":[{"given":"Diana","family":"Bittersohl","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medical Center Hamburg\u2010Eppendorf Hamburg 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