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Six hours after baseline, the animals were killed and the eyes were histologically and immunohistochemically examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In experimental models in the high\u2010<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> group and the low\u2010<jats:styled-content style=\"fixed-case\">CSFP<\/jats:styled-content> group as compared to the control group, <jats:styled-content style=\"fixed-case\">RGC<\/jats:styled-content> axons became abnormally dilated and accumulated vesicles. Both groups as compared to the control group showed an accumulation of dynein <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> (intermediate chain) at the optic nerve head and retina and a reduction in kinesin <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (heavy chain) immunoreactivity in the optic nerve fibre axons. As a corollary, Western blot analysis revealed an elevation of dynein <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> protein levels in the optic nerve head and retina and a decrease in kinesin <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> protein levels in the optic nerve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Experimental models with an acute <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> rise or with an acute <jats:styled-content style=\"fixed-case\">CSFP<\/jats:styled-content> reduction showed similar morphologic changes in the retinal ganglion cell axons and similar immunohistochemical changes in the axonal motor proteins kinesin <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> and dynein <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>. It supports the hypothesis that an experimental model with an acute reduction in <jats:styled-content style=\"fixed-case\">CSFP<\/jats:styled-content> as well as an experimental model with an acute rise in <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> may share similarities in the process of optic nerve damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12768","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T20:59:58Z","timestamp":1436907598000},"page":"266-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dynein, kinesin and morphological changes in optic nerve axons in a rat model with cerebrospinal fluid pressure reduction: the Beijing Intracranial and Intraocular Pressure (iCOP) study"],"prefix":"10.1111","volume":"94","author":[{"given":"Zheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China"},{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing China"},{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kegao","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjun","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China"},{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningli","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China"},{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12811"},{"key":"e_1_2_5_3_1","first-page":"771","article-title":"Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve","volume":"13","author":"Anderson DR","year":"1974","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.01-1282"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.01.013"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2228"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70113-X"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0807-1"},{"key":"e_1_2_5_10_1","first-page":"1593","article-title":"Selective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus","volume":"32","author":"Dandona L","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt505"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12551"},{"key":"e_1_2_5_13_1","first-page":"838","article-title":"Axoplasmic flow during chronic experimental glaucoma. 1. 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