{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:43:59Z","timestamp":1791020639773,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sigvard & Marianne Bernadotte Foundation"},{"name":"Signhild Engkvist Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To report prevalence, ocular characteristics and coexisting neurological, behavioural, somatic and neuroradiological abnormalities in children and adolescents with morning glory disc anomaly (\n                      <jats:styled-content style=\"fixed-case\">MGDA<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a cross\u2010sectional population\u2010based study, 12 patients with\n                      <jats:styled-content style=\"fixed-case\">MGDA<\/jats:styled-content>\n                      , aged 2\u201320\u00a0years, were identified. All 12 agreed to ophthalmological assessments including visual functions, refraction, fundus photography, optical coherence tomography (\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      ) and ocular motor score (\n                      <jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content>\n                      ). Neurological examinations and behavioural\/developmental screening were carried out. Data from previous or new neuroradiological investigations were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of\n                      <jats:styled-content style=\"fixed-case\">MGDA<\/jats:styled-content>\n                      was 2.6\/100\u00a0000.\n                      <jats:styled-content style=\"fixed-case\">MGDA<\/jats:styled-content>\n                      was unilateral in 11\/12 patients with a best\u2010corrected visual acuity (\n                      <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>\n                      ) in the\n                      <jats:styled-content style=\"fixed-case\">MGDA<\/jats:styled-content>\n                      eye ranging from hand motion to 0.65 (median 0.06). Severe microphthalmus prevented unilaterality to be determined in one adolescent. All patients had a binocular\n                      <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>\n                      of \u22650.5.\n                      <jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content>\n                      showed abnormalities in pupil response, vestibulo\u2010ocular reflex, stereo visual acuity, strabismus and convergence.\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      revealed peripapillary or macular oedema in 5\/8 patients and foveal aplasia in 3\/8 patients. Three patients had extensive capillary hemangiomas, of which one had\n                      <jats:styled-content style=\"fixed-case\">PHACES<\/jats:styled-content>\n                      syndrome and one had additional cerebrovascular anomalies and corpus callosum agenesis. Neuroradiology showed craniovascular anomalies in two patients. Neurology was mostly normal. Behavioural\/developmental screening showed attention deficit hyperactivity disorder in one patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The prevalence data, previously not reported, of morning glory disc anomaly was 2.6\/100 000. Coexisting retinal peripapillary or macular oedema was common, as were cerebral abnormalities and\/or cutaneous vascular malformations. The associated findings may not be discovered through routine ophthalmological examination why\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      and neuroimaging are called for.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.12778","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:41:52Z","timestamp":1436892112000},"page":"626-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Morning Glory Disc Anomaly in childhood \u2013 a population\u2010based study"],"prefix":"10.1111","volume":"93","author":[{"given":"Dylan J","family":"Ceynowa","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm 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