{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:43:10Z","timestamp":1787168590342,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the visual field rate of progression of patients with treated ocular hypertension (<jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content>) and primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>) in clinical practice, using the mean deviation (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) and the visual field index (<jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2010interventional cohort study. From a large multicentre database representative of the French population, 441 eyes of 228 patients with treated <jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> followed up at least 6\u00a0years with Humphrey 24.2 Sita\u2010Standard visual field examination at least twice a year were identified. From initial data, eyes were classified in five groups: 121 with <jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content>, 188 with early glaucoma (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> greater than \u22126\u00a0dB), 45 with moderate glaucoma (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u22126 to \u221212\u00a0dB), 41 with advanced glaucoma (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u221212 to \u221218\u00a0dB) and 46 with severe glaucoma (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> less than \u221218\u00a0dB). Rate of progression during the follow\u2010up period was calculated using the trend analysis of the Guided Progression Analysis software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean duration of follow\u2010up was 8.4\u00a0\u00b1\u00a02.7\u00a0years and the mean number of visual field, 18.4\u00a0\u00b1\u00a03.5. In eyes with <jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content>, rate of progression was \u22120.09\u00a0dB\/year (\u22120.17%<jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>\/year). In eyes with <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>, rate of progression was \u22120.32\u00a0dB\/year (\u22120.83%<jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>\/year) in eyes with early glaucoma, \u22120.52\u00a0dB\/year (\u22121.81%<jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>\/year) in moderate glaucoma, \u22120.54\u00a0dB\/year (\u22122.35%<jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>\/year) in advanced glaucoma and \u22120.45\u00a0dB\/year (\u22121.97%<jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>\/year) in severe glaucoma. In eyes with <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>, a significant progression (p\u00a0&lt;\u00a00.05) was detected in 159 of 320 eyes (49.7%) with trend analysis and 117 of 320 eyes (36.6%, likely progression) or 183 of 320 eyes (57.2%, possible and likely progression) with event analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary open\u2010angle glaucoma is a progressive disease in the majority of patients despite cautioned treatment and follow\u2010up. The rate of progression varies greatly among subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12788","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T23:45:48Z","timestamp":1434757548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Progression of visual field in patients with primary open\u2010angle glaucoma \u2013 <scp>P<\/scp>rog<scp>F<\/scp> study 1"],"prefix":"10.1111","volume":"93","author":[{"given":"Florent","family":"Aptel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology CHU Grenoble Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishal","family":"Aryal\u2010Charles","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology CHU Grenoble Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Giraud","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology HIA du Val de Gr\u00e2ce Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam","family":"El Chehab","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology HIA du Val de Gr\u00e2ce Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Delbarre","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology HIA du Val de Gr\u00e2ce Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Chiquet","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology CHU Grenoble Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Romanet","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology CHU Grenoble Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology HIA du Val de Gr\u00e2ce Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Preferred practice pattern\u00ae guidelines. 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