{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:05:10Z","timestamp":1759939510767},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the cost and effects of risk factor guided screening strategies for retinopathy of prematurity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data from the Netherlands Retinopathy of Prematurity study (<jats:styled-content style=\"fixed-case\">NEDROP<\/jats:styled-content> study) that included all infants screened for <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> and born in 2009 were used to assess the cost and effects of several screening strategies for <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> using different criteria: (1) gestational age (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>), (2) birthweight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>), (3) combined <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> and (4) combined <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> and presence of risk factors. Two treatment strategies were evaluated: the infants actually treated in the <jats:styled-content style=\"fixed-case\">NEDROP<\/jats:styled-content> study (<jats:italic>n<\/jats:italic>\u00a0=\u00a017) and all infants detected with severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most efficient screening strategy to include all infants treated for both treatment strategies is to screen all infants with a <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> of 30\u00a0weeks or less and a <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> of 1250\u00a0g or lower together with infants with a <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> of 30\u201332\u00a0weeks and a <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> of 1250\u20131500\u00a0g with at least one risk factor. The marginal cost ranged from \u20ac43\u00a0848 to \u20ac 226\u00a0914 per additional infant with improved vision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current Dutch guideline may be improved: the same effectiveness can be obtained for lower costs. Releasing the precondition that no infants with severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> might be missed will lead to lower costs, but this will also lead to a lower number of infants with improved visual acuity. The costs of detecting all infants with severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> seem acceptable for society when the <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content> gain and savings from a societal perspective resulting from improved vision are taken into account.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12798","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T07:43:17Z","timestamp":1436168597000},"page":"706-712","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cost and effects of risk factor guided screening strategies for retinopathy of prematurity for different treatment strategies"],"prefix":"10.1111","volume":"93","author":[{"given":"M. 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