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After a complete ophthalmic examination, all eyes were imaged with <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RTV<\/jats:styled-content>ue\u2010100 version 5.1 Fourier\u2010domain optical coherence tomography; Optovue Inc., Fremont, CA, USA); <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and choroidal thickness were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> thicknesses were 209.4\u00a0\u00b1\u00a040.2\u00a0\u03bcm in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and 292.5\u00a0\u00b1\u00a033.7\u00a0\u03bcm in control subjects. There was a significant difference in the mean <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> thickness between the groups (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). The choroidal thickness measurements of the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group at the subfoveal region and 1.5\u00a0mm temporal and 1.5\u00a0mm nasal to the fovea were 228.1\u00a0\u00b1\u00a044.3, 193.2\u00a0\u00b1\u00a041.4 and 188.4\u00a0\u00b1\u00a049.0\u00a0\u03bcm, respectively, whereas measurements for the controls were, respectively, 246.5\u00a0\u00b1\u00a038.2, 227.3\u00a0\u00b1\u00a034.7 and 216.7\u00a0\u00b1\u00a051.4\u00a0\u03bcm. The choroid was significantly thinner in eyes of the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group compared to that of the controls (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001, and p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006). There was no significant correlation between the disease severity and <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> parameters. The duration of the disease showed a statistically significant negative correlation with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> (<jats:italic>rs<\/jats:italic>[94]\u00a0=\u00a0\u22120.700, p\u00a0&lt;\u00a00.001), and average subfoveal and temporal and nasal choroid thicknesses (<jats:italic>rs<\/jats:italic>[94]\u00a0=\u00a0\u22120.282, p\u00a0=\u00a00.006; <jats:italic>rs<\/jats:italic>[94]\u00a0=\u00a0\u22120.324, p\u00a0=\u00a00.001, <jats:italic>rs<\/jats:italic>[94]\u00a0=\u00a0\u22120.240, and p\u00a0=\u00a00.020, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Regardless of the disease severity, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> may cause atrophy and volume loss in the lamina cribrosa, and choroid. An enhanced depth imaging technique may be used as an additional modality in the diagnosis and follow\u2010up of patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12809","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T11:38:29Z","timestamp":1439465909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The choroid and lamina cribrosa is affected in patients with Parkinson's disease: enhanced depth imaging optical coherence tomography study"],"prefix":"10.1111","volume":"94","author":[{"given":"Muhsin","family":"Eraslan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eren","family":"Cerman","sequence":"additional","affiliation":[{"name":"Department of 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