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(Rillieux-la-Pape, France)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the efficacy and safety of the ultrasonic circular cyclocoagulation procedure in patients with open\u2010angle glaucoma na\u00efve of previous filtering surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective non\u2010comparative interventional clinical study conducted in five French University Hospitals. Thirty eyes of 30 patients with open\u2010angle glaucoma, intra\u2010ocular pressure (IOP)\u00a0&gt;\u00a021\u00a0mmHg and with no previous filtering glaucoma surgeries were sonicated with a probe comprising six piezoelectric transducers. The six transducers were activated with a 6\u2010s exposure time. Complete ophthalmic examinations were performed before the procedure and at 1\u00a0day, 1\u00a0week, 1, 2, 3, 6 and 12\u00a0months after the procedure. Primary outcomes were qualified surgical success (defined as IOP reduction from baseline \u226520% and IOP\u00a0&gt;\u00a05\u00a0mmHg with possible re\u2010intervention and without hypotensive medication adjunction) and complete surgical success (defined as IOP reduction from baseline \u226520%, IOP\u00a0&gt;\u00a05\u00a0mmHg and IOP\u00a0&lt;\u00a021\u00a0mmHg with possible re\u2010intervention and without hypotensive medication adjunction) at the last follow\u2010up visit and vision\u2010threatening complications. Secondary outcomes were mean IOP at each follow\u2010up visit compared with baseline, medication use, complications and re\u2010interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010ocular pressure was significantly reduced (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) from a mean pre\u2010operative value of 28.2\u00a0\u00b1\u00a07.2\u00a0mmHg (<jats:italic>n\u00a0<\/jats:italic>=\u00a03.6 hypotensive medications) to 19.6\u00a0\u00b1\u00a07.9\u00a0mmHg at 12\u00a0months (<jats:italic>n<\/jats:italic>\u00a0=\u00a03.1 hypotensive medications and <jats:italic>n<\/jats:italic>\u00a0=\u00a01.1 procedures) (mean IOP reduction of 30%). Qualified success was achieved in 63% of eyes (19\/30) (mean IOP reduction of 37% in these eyes) and complete success in 46.7% of eyes (14\/30) (mean IOP reduction of 37% in these eyes) at the last follow\u2010up. No major intra\u2010 or post\u2010operative complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The UC<jats:sup>3<\/jats:sup> procedure seems to be an effective and well\u2010tolerated method to reduce IOP in patients with open\u2010angle glaucoma without previous filtering surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12913","type":"journal-article","created":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T19:43:11Z","timestamp":1447011791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Multicenter clinical trial of high\u2010intensity focused ultrasound treatment in glaucoma patients without previous filtering surgery"],"prefix":"10.1111","volume":"94","author":[{"given":"Florent","family":"Aptel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital, CHU Grenoble, Joseph Fourier University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Denis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Rouland","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Claude Huriez Hospital CHRU de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Val de Grace Military Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bron","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital, CHU Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"526","article-title":"Transscleral neodymium: YAG laser cyclophotocoagulation for end\u2010stage glaucoma, refractory glaucoma, and painful blind eyes","volume":"24","author":"Al\u2010Ghamdi S","year":"1993","journal-title":"Ophthalmic Surg"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2012.665566"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5135"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8137"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.910509"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2014.04.017"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30109-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067219500500106"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33672-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2011.01.017"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71696-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)34028-9"},{"key":"e_1_2_5_14_1","first-page":"189","article-title":"Cryosurgery for the treatment of glaucoma","volume":"63","author":"De Roetth A","year":"1965","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14973"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.3.345"},{"key":"e_1_2_5_17_1","first-page":"CD007059","article-title":"Non\u2010penetrating filtration surgery versus trabeculectomy for open\u2010angle glaucoma","volume":"2","author":"Eldaly MA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_18_1","first-page":"125","article-title":"Treatment of refractory glaucomas by transscleral cyclophotocoagulation using semiconductor diode laser. 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