{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:13:42Z","timestamp":1762899222436},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:00:00Z","timestamp":1446854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["ZIAEY000401"],"award-info":[{"award-number":["ZIAEY000401"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine whether adults, aged 66\u201396\u00a0years, with exfoliation syndrome (<jats:styled-content style=\"fixed-case\">XFS<\/jats:styled-content>)\/exfoliation glaucoma (<jats:styled-content style=\"fixed-case\">XFG<\/jats:styled-content>), or primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>) have poorer hearing than controls of similar age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case (<jats:styled-content style=\"fixed-case\">XFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">XFG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>) and control status was diagnosed in the Reykjavik Glaucoma Studies (<jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>) using slit\u2010lamp examination, visual field testing and optic disc photographs; the <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content> data were merged with the Age, Gene\/Environment Susceptibility\u2013Reykjavik Study that collected hearing data using air\u2010conduction, pure\u2010tone thresholds obtained at 0.5, 1, 2, 3, 4, 6 and 8\u00a0kHz categorized by better ear and worse ear, based on pure\u2010tone averages (<jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content>s) calculated separately for low and middle frequencies (<jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content><jats:sub>512<\/jats:sub> \u2013 mean of thresholds at 0.5, 1 and 2\u00a0kHz) and high frequencies (<jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content><jats:sub>3468<\/jats:sub> \u2013 mean of thresholds at 3, 4, 6 and 8\u00a0kHz). Multivariable linear regression was used to test for differences in <jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content>s between cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age for 158 <jats:styled-content style=\"fixed-case\">XFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">XFG<\/jats:styled-content> cases (30.4% male) was 77.4\u00a0years, 95 <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> cases (35.8% male) was 77.9\u00a0years, and 123 controls (46.3% male) was 76.8\u00a0years. Using multivariable linear regression analysis, there were no consistent, statistically significant differences in <jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content>s between the two case groups and controls in either the low\u2010 or high\u2010frequency range, even when stratified by age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among the older individuals examined in this study hearing loss is highly prevalent and strongly associated with male gender and increasing age. As we did not find consistent statistically significant difference in hearing between cases and controls the diagnosis of <jats:styled-content style=\"fixed-case\">XFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">XFG<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> does not as such routinely call for audiological evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12914","type":"journal-article","created":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T19:43:15Z","timestamp":1447011795000},"page":"140-146","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hearing in older adults with exfoliation syndrome\/exfoliation glaucoma or primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"94","author":[{"given":"Geir","family":"Tryggvason","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fridbert","family":"Jonasson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Landspitali University Hospital Reykjavik Iceland"},{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Frances","family":"Cotch","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Clinical Applications National Eye Institute (NEI) National Institutes of Health (NIH) Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan\u2010Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Epidemiology and Statistics Program National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health (NIH) Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard 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