{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:44:35Z","timestamp":1772801075494,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To analyse structural changes in conjunctiva, sclera and Schlemm's canal (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) following canaloplasty with optical coherence tomography (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) and ultrasound biomicroscopy (<jats:styled-content style=\"fixed-case\">UBM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients undergoing canaloplasty were included in this prospective study. <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> images were acquired pre\u2010 and 1, 7, 30 and 90\u00a0days postoperatively. <jats:styled-content style=\"fixed-case\">UBM<\/jats:styled-content> was performed 3\u00a0months postoperatively. The surgical site was evaluated for the presence of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, transscleral filtration, a scleral lake and the visibility of intra\u2010Schlemm\u2010sutures. The height and width of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> were measured at the 3 and 9 o'clock limbus position.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After canaloplasty, <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> was detectable with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> in 93% of the patients on day 1. The increase in height was higher than that in width (height: +369%, p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.0004, width: +152%, p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.002). <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was negatively correlated to <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>'s width 1\u00a0week postoperatively (<jats:italic>r\u00a0=\u00a0<\/jats:italic>\u22120.63, p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.04) and to SC's height until 3 months (<jats:italic>r\u00a0=\u00a0<\/jats:italic>\u22120.66, p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.02) postoperatively. Using <jats:styled-content style=\"fixed-case\">UBM<\/jats:styled-content>, a reflection of the traction sutures indicated <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>'s position in all patients. Transscleral filtration was found in all patients using <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>, demonstrating a peak 1\u00a0week postoperatively. At 3\u00a0months, a scleral lake could be visualized in 50% and 83% of patients using <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UBM<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> offers a high resolution for imaging superficial conjunctival areas and <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> after canaloplasty, whereas <jats:styled-content style=\"fixed-case\">UBM<\/jats:styled-content> is capable of detecting deeper structures such as scleral lakes or intra\u2010canal\u2010sutures. The results imply a correlation of the dilation of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> with the <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010lowering effect and an early pronounced transscleral filtration following canaloplasty.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12917","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T17:58:26Z","timestamp":1449683906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of early anatomical changes following canaloplasty with anterior segment spectral\u2010domain optical coherence tomography and ultrasound biomicroscopy"],"prefix":"10.1111","volume":"94","author":[{"given":"Matthias","family":"Fuest","sequence":"first","affiliation":[{"name":"Department of Ophthalmology RWTH Aachen University Aachen 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