{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:32:22Z","timestamp":1780551142379,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To search for histomorphometric differences between eyes with primary high myopia (PHM<\/jats:styled-content>) or secondary high axial myopia (SHM<\/jats:styled-content>) caused by congenital glaucoma, and non\u2010highly myopic eyes (NHM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Histologic anterior\u2013posterior sections were histomorphometrically examined.<\/jats:p><\/jats:sec>Results<\/jats:title>The investigation included 58 human globes (mean age: 61.5\u00a0\u00b1\u00a018.5\u00a0years; axial length: 27.3\u00a0\u00b1\u00a04.0\u00a0mm; range: 21.0\u201339.0\u00a0mm). Bruch's membrane thickness was thinner in SHM<\/jats:styled-content> than in PHM<\/jats:styled-content> (posterior pole: p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.007; parapapillary region: p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.007); midpoint posterior pole\/equator\u00a0=\u00a00.05) and thinner in SHM<\/jats:styled-content> than in NHM<\/jats:styled-content> (all p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.04), while PHM<\/jats:styled-content> and NHM<\/jats:styled-content> did not differ (all p\u00a0<\/jats:italic>>\u00a0<\/jats:italic>0.50). Choroidal thickness did not differ (all p\u00a0<\/jats:italic>\u2265\u00a0<\/jats:italic>0.40) at any measurement location between SHM<\/jats:styled-content> and PHM<\/jats:styled-content>, and was thinner (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05) in both myopic groups than in NHM<\/jats:styled-content>. Posterior sclera was thinner (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) in both myopic groups than in NHM<\/jats:styled-content>, with no significant difference between both myopic groups. Pars plana scleral thickness was thinner (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.02) in SHM<\/jats:styled-content> than in PHM<\/jats:styled-content> after adjusting for axial length. Scleral volume (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.41) and choroidal volume (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.74) did not differ between any of the groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Thinning of Bruch's membrane overall is typical for SHM<\/jats:styled-content> while eyes with PHM<\/jats:styled-content> have a normal Bruch's membrane thickness. It may point to Bruch's membrane as an active part in the process of emmetropization\/myopization. SHM<\/jats:styled-content> in contrast to PHM<\/jats:styled-content> showed scleral thinning in the pars plana region suggesting that the process of emmetropization\/myopization takes place posterior to the pars plana. Both SHM<\/jats:styled-content> and PHM<\/jats:styled-content> unspecifically showed an axial length associated with thinning of choroid and posterior sclera, while both myopic groups did not differ with NHM<\/jats:styled-content> in choroidal and scleral volume.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12937","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T05:40:45Z","timestamp":1450849245000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim Heidelberg University Mannheim 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