{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:35:51Z","timestamp":1773887751708,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the relationship between retinal vascular calibre and cardiovascular risk factors in a Japanese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Locomotive Syndrome and Health Outcome in Aizu Cohort Study is a population\u2010based, cross\u2010sectional survey that included 2346 persons (56.1% of the eligible population) aged 40 to 74\u00a0years old. Retinal vascular calibre was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1787 participants with available retinal vascular calibre data, the mean retinal arteriolar calibre (<jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>) was 141.6\u00a0\u00b1\u00a018.6\u00a0<jats:italic>\u03bc<\/jats:italic>m, the mean venular calibre (<jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content>) was 209.3\u00a0\u00b1\u00a026.1\u00a0<jats:italic>\u03bc<\/jats:italic>m, and the mean arteriole\u2010to\u2010venule ratio was 0.68\u00a0\u00b1\u00a00.08. A smaller <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> was associated with male sex, increasing quartiles of systolic blood pressure and diastolic blood pressure, history of hypertension, current alcohol intake and higher quartiles of serum creatinine. A larger <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> was associated with increasing quartiles of total cholesterol. A larger <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content> was associated with current cigarette smoking. Multivariate analyses showed that a smaller <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> was associated with male sex, elevated mean arterial blood pressure and a history of hypertension; and a larger <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content> was associated with cigarette smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that a narrowed diameter of the retinal arteriole in Japanese people is related to hypertension and sex (male) and that an enlarged retina venular diameter is related to a history of smoking. The pattern of these associations is similar to that in white populations and other Asian populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12953","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T08:03:36Z","timestamp":1453709016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Retinal vessel diameters in a Japanese population: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study"],"prefix":"10.1111","volume":"94","author":[{"given":"Takatoshi","family":"Tano","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Juntendo Tokyo Koto Geriatric Medical Center Tokyo 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