{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:16:20Z","timestamp":1789146980404,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the postoperative risk of inflammatory relapse in two groups of uveitic patients who underwent cataract surgery: one group had perioperative topical steroids alone and the other used topical and oral steroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, randomized, unmasked, duocentric clinical trial conducted at the University of Parma (Italy), and the Jules Gonin Eye Hospital of Lausanne (Switzerland). Patients with a history of non\u2010infectious uveitis requiring cataract surgery in 2009\u20132013 were assigned to two groups of perioperative prophylaxis: (A) intensive topical steroids alone; (B) the same topical regimen combined with oral steroids. Uveitis relapse over a period of 6\u00a0months was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 52 eyes in 50 patients were randomized: 28 eyes were assigned to group A (topical) and 24 eyes to group B (topical + oral). Mean relapse\u2010free survival time was 131\u00a0\u00b1\u00a011\u00a0days in group A and 150\u00a0\u00b1\u00a013\u00a0days in group B. This difference was not statistically significant (p\u00a0=\u00a00.42). At the end of follow\u2010up, the groups were also comparable in terms of significant improvement in visual acuity (p\u00a0&lt;\u00a00.01), mean central macular thickness (<jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Absolute and long\u2010lasting control of ocular, and possibly systemic, inflammation predisposes uveitis patients to satisfactory results after cataract extraction and intraocular lens implantation. Despite a lower rate of recurrences following oral steroid supplementation, the efficacy of an intensive perioperative topical steroid regimen alone in preventing postoperative uveitis relapse was statistically comparable. Secondary outcomes were also comparable between the two groups. Transient <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> elevation should be expected until treatment discontinuation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12955","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T07:48:08Z","timestamp":1454658488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Perioperative prophylaxis to prevent recurrence following cataract surgery in uveitic patients: a two\u2010centre, prospective, randomized trial"],"prefix":"10.1111","volume":"94","author":[{"given":"Paolo","family":"Mora","sequence":"first","affiliation":[{"name":"Institute of Ophthalmology University Hospital of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology University Hospital of Parma Parma 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