{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:30:25Z","timestamp":1790199025141,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dr. F.P. Fischer Foundation"},{"DOI":"10.13039\/501100010329","name":"SNOO Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010302","name":"Algemene Nederlandse Vereniging ter Voorkoming van Blindheid","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010302","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010332","name":"Stichting Winckel-Sweep","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Up to one\u2010third of patients with intra\u2010ocular silicone oil (SO) tamponade for complex macula\u2010on retinal detachment may experience an unexplained visual loss during or after SO tamponade. Although the underlying mechanism is unknown, previous studies suggested that accumulation of retinal potassium could be involved. Hence, this study tested the hypothesis that intra\u2010ocular potassium levels are elevated during SO tamponade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective cohort study was carried out from 13 October 2013 through 5 March 2015. Potassium, sodium, magnesium, chloride, calcium, lactate dehydrogenase (LDH) and glucose levels were measured in retro\u2010oil fluid and paired serum from 16 patients undergoing oil removal, including two patients with SO\u2010related visual loss (SORVL). Vitreous humour and paired serum from 27 patients with macular hole (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019) or floaters (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08) served as controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median potassium levels in retro\u2010oil fluid and vitreous humour were similar. Magnesium and chloride levels were lower in retro\u2010oil fluid compared with vitreous humour (p\u00a0&lt;\u00a00.01) and LDH levels were elevated in retro\u2010oil fluid (p\u00a0&lt;\u00a00.0001). One of the two patients with SORVL revealed abnormal high potassium and magnesium levels. The other patient had normal levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Potassium levels are not increased in retro\u2010oil fluid during SO tamponade, making the \u2018potassium accumulation\u2019 hypothesis unlikely. The disturbance in magnesium concentration during SO tamponade warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.12959","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T02:33:22Z","timestamp":1453689202000},"page":"449-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Electrolyte composition of retro\u2010oil fluid and silicone oil\u2010related visual loss"],"prefix":"10.1111","volume":"94","author":[{"given":"Laura M. E.","family":"Scheerlinck","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas J. W.","family":"Kuiper","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht the Netherlands"},{"name":"Laboratory of Translational Immunology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert T. A.","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A. W. J. F.","family":"Schellekens","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redmer","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-013-9684-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328979"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00800-X"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12307"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.053561"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02248.x"},{"key":"e_1_2_5_8_1","first-page":"590","article-title":"The use of liquid silicone in retinal detachment surgery","volume":"68","author":"Cibis P","year":"1962","journal-title":"JAMA Ophthalmol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2033-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069132"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12212"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.082610"},{"key":"e_1_2_5_13_1","first-page":"130","article-title":"Intraocular silicone oil tamponade. 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