{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:56Z","timestamp":1790856656101,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Elevated intra\u2010ocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) has been identified as a major risk factor for glaucoma. Additionally, extensive literature depicts a vascular dysfunction to exist in these patients. However, a large ocular blood flow\u2010oriented trial to integrate these findings in the clinical setting is lacking. This study would likely help to identify which of these vascular data can be used as a clinical tool for screening and disease stratification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Prospective, cross\u2010sectional, case\u2013control hospital\u2010based study. Patients with primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>), normal\u2010tension glaucoma (<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>), ocular hypertension (<jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content>), glaucoma suspects and healthy volunteers were recruited. In addition to a comprehensive ophthalmological examination, a vascular\u2010oriented questionnaire was completed and ocular blood flow assessment (colour Doppler imaging of retrobulbar vessels, retinal oximetry, dynamic contour tonometry, optical coherent tomography enhanced\u2010depth imaging of the choroid) were performed. Statistical analysis was based on multiple imputation to account for missingness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 614 subjects (291 males) were recruited between March and December 2013 (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>: 214, <jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>: 192; <jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content>: 27; glaucoma suspect: 41; healthy controls: 140). Glaucoma groups (NTG and POAG) were age and gender matched with the control group (p\u00a0&gt;\u00a00.05). Glaucoma groups were paired in terms of functional and structural parameters (p\u00a0&gt;\u00a00.08). Mean ocular perfusion pressure was higher in the glaucoma groups than in controls (p\u00a0&lt;\u00a00.001). Glaucoma groups had lower retrobulbar velocities, higher retinal venous saturation and choroidal thickness asymmetries when compared to the healthy group, in line with the current literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Leuven Eye Study stands as one of the largest clinical trials on ocular blood flow in glaucoma. The creation of this vast database may help integrate the vascular aspects of glaucoma into the clinical practice of glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12962","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T20:21:12Z","timestamp":1455999672000},"page":"592-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Ocular blood flow in glaucoma \u2013 the Leuven Eye Study"],"prefix":"10.1111","volume":"94","author":[{"given":"Lu\u00eds","family":"Abeg\u00e3o Pinto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospitals Leuven Leuven Belgium"},{"name":"Visual Sciences Study Center Faculty of Medicine of Lisbon University Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Willekens","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospitals Leuven 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