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Subjects were divided into mild, moderate and severe groups according to the glaucoma staging system 2. The two POAG<\/jats:styled-content> subtypes, normal tension glaucoma (NTG<\/jats:styled-content>) and hypertension glaucoma (HTG<\/jats:styled-content>) were classified according to peak IOP<\/jats:styled-content> values throughout the 24\u2010hr period. The 24\u2010hr IOP<\/jats:styled-content> curves were obtained based on the average IOP<\/jats:styled-content> value at each time\u2010point. The mean, peak, trough and fluctuation of IOP<\/jats:styled-content> together with the diurnal\u2010to\u2010nocturnal IOP<\/jats:styled-content> change were calculated and compared among different groups.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 160 POAG patients (84 NTG<\/jats:styled-content> and 76 HTG<\/jats:styled-content>) were enrolled in the study. Generally, IOP<\/jats:styled-content> decreased in the diurnal period and increased progressively during the nocturnal period, with peak IOP<\/jats:styled-content> occurring from 2:00\u00a0AM<\/jats:styled-content> to 10:00\u00a0AM<\/jats:styled-content>. The average IOP<\/jats:styled-content> values at all time\u2010points were significantly higher in the mild group compared to the moderate and severe groups (p\u00a0<\u00a00.05). Compared with the NTG<\/jats:styled-content> subjects, the IOP<\/jats:styled-content> parameters including mean, peak, trough and fluctuation were significantly higher in the HTG<\/jats:styled-content> subjects (p\u00a0<\u00a00.001), and IOP<\/jats:styled-content> increased more predominantly in the HTG<\/jats:styled-content> subtype during the nocturnal period.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There was some regularity in the 24\u2010hr IOP<\/jats:styled-content> pattern in POAG<\/jats:styled-content>, but different severities of GON<\/jats:styled-content> and different subtypes might present different characteristics. Other non\u2010IOP<\/jats:styled-content> factors may lead to pathological IOP<\/jats:styled-content> fluctuation and could be correlated with GON<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12963","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T07:30:08Z","timestamp":1454571008000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Twenty\u2010four\u2010hour pattern of intra\u2010ocular pressure in untreated patients with primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"94","author":[{"given":"Jingyi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital Shanghai Medical College of Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health (Fudan University) Shanghai China"},{"name":"Shanghai Key Laboratory of Visual 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