{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:16:42Z","timestamp":1763389002801},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the clinical outcomes of intravitreal bevacizumab (<jats:styled-content style=\"fixed-case\">IVB<\/jats:styled-content>) injection, with different dosing (0.25\u00a0mg\/0.01\u00a0ml versus 0.625\u00a0mg\/0.025\u00a0ml) in each eye of the same patient with retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intravitreal bevacizumab (IVB) was injected into eight patients with stage 3+ in zone I or posterior zone <jats:styled-content style=\"fixed-case\">II ROP<\/jats:styled-content> (16 eyes). Bevacizumab, with different dosing (0.25\u00a0mg\/0.01\u00a0ml and 0.625\u00a0mg\/0.025\u00a0ml), was injected into the vitreous cavity of each eye.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 16 eyes treated with <jats:styled-content style=\"fixed-case\">IVB<\/jats:styled-content>, six eyes had zone I <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> and 10 eyes had zone <jats:styled-content style=\"fixed-case\">II ROP<\/jats:styled-content>. The mean birthweight was 800\u00a0\u00b1\u00a0139\u00a0g (range, 533\u2013955\u00a0g), and the mean gestational age was 25.9\u00a0\u00b1\u00a01.2 gestational weeks (range, 24.4\u201328.7\u00a0weeks). The postmenstrual age at initial treatment was 37.2 gestational weeks (range, 33.7\u201341\u00a0weeks). The mean follow\u2010up was 312\u00a0\u00b1\u00a050\u00a0days (median, 305\u00a0days; range, 238\u2013376\u00a0days). All eyes showed regression of plus sign after <jats:styled-content style=\"fixed-case\">IVB<\/jats:styled-content> injection within 1\u00a0week and revascularization to the ora serrata at the time of final visit. There was no difference in the time of anatomical achievement between the eyes with different doses. None of the patients received any additional <jats:styled-content style=\"fixed-case\">IVB<\/jats:styled-content> injection or laser photocoagulation. After the regression of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>, tractional retinal detachment and macular ectopia were not observed in any patients during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no difference in the short\u2010term clinical outcomes of stage 3+ <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> in zone I or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> between the eyes with low dose and conventional dose of <jats:styled-content style=\"fixed-case\">IVB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13004","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T09:51:06Z","timestamp":1458813066000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Low dose versus conventional dose of intravitreal bevacizumab injection 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