{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T17:22:25Z","timestamp":1770398545794,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the effect of intravitreal bevacizumab for Type 1 retinopathy of prematurity (ROP) in zone II <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a randomized clinical trial. Preterm infants with a gestational age less than 34\u00a0weeks or birthweight less than 2000\u00a0g were examined at 4\u00a0weeks chronological age or 31\u00a0weeks postmenstrual age (whichever was later). Preterm infants with Zone\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\/Stage 2 or 3 and plus disease were included. Eligible infants were randomized to receive either conventional indirect laser therapy or intravitreal bevacizumab injections (0.625\u00a0mg\/0.025\u00a0ml). The primary outcome was defined as treatment failure: <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> persistence or recurrence by 90\u00a0weeks postmenstrual age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study population comprised 79 infants (158 eyes) with Zone\u2010<jats:styled-content style=\"fixed-case\">II ROP<\/jats:styled-content>. Randomly, 43 infants (86 eyes) were assigned to receive intravitreal bevacizumab and 36 infants (72 eyes) to receive conventional indirect laser therapy. All the infants were followed up at least until 90\u00a0weeks postmenstrual age. Stage\u20103 <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> recurred in nine eyes (10.5%) in the bevacizumab group and one eye (1.4%) in the laser group (p value\u00a0=\u00a00.018). In recurrent cases after the second treatment, <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> in eight of the nine eyes (88.8%) in the bevacizumab group and the eye in the laser group regressed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recurrence of neovascularization with bevacizumab monotherapy seems to be higher than that with conventional laser therapy among infants with Type 1 ROP in zone II <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> but reinjection of bevacizumab causes regression in most recurrent cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13008","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T10:02:57Z","timestamp":1458813777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Efficacy of intravitreal bevacizumab for zone\u2010<scp>II<\/scp> retinopathy of prematurity"],"prefix":"10.1111","volume":"94","author":[{"given":"Reza","family":"Karkhaneh","sequence":"first","affiliation":[{"name":"Eye Research Center Farabi Eye Hospital Tehran University of Medical Science (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Khodabande","sequence":"additional","affiliation":[{"name":"Eye Research Center Farabi Eye Hospital Tehran University of Medical Science (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Riazi\u2010Eafahani","sequence":"additional","affiliation":[{"name":"Eye Research Center Farabi Eye Hospital Tehran University of Medical Science (TUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramak","family":"Roohipoor","sequence":"additional","affiliation":[{"name":"Eye Research Center Farabi Eye Hospital Tehran University of Medical Science (TUMS) Tehran 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