{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:50:10Z","timestamp":1791960610228,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Adenomas of the ciliary pigment epithelium (<jats:styled-content style=\"fixed-case\">CPE<\/jats:styled-content>) are rare benign tumours which have mainly to be differentiated from malignant ciliary body melanomas. Here we report on a consecutive series of patients with <jats:styled-content style=\"fixed-case\">CPE<\/jats:styled-content> adenomas and describe their characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective hospital\u2010based case series study included all patients who were consecutively operated for <jats:styled-content style=\"fixed-case\">CPE<\/jats:styled-content> adenomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 110 patients treated for ciliary body tumours, five patients (4.5%) had a <jats:styled-content style=\"fixed-case\">CPE<\/jats:styled-content> adenoma. Mean age was 59.0\u00a0\u00b1\u00a09.9\u00a0years (range: 46\u201372\u00a0years). Mean tumour apical thickness was 6.6\u00a0\u00b1\u00a01.7\u00a0mm. Tumour colour was mostly homogenously brown to black, and the tumour surface was smooth. The tumour masses pushed the iris tissue forward without infiltrating iris or anterior chamber angle. Sonography revealed an irregular echogram with sharp lesion borders and signs of blood flow in Color Doppler flow imaging. Ultrasonographic biomicroscopy demonstrated medium\u2010low internal reflectivity and acoustic attenuation. In magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), the tumours as compared to brain were hyperintense on T1\u2010weighted images and hypointense on T2\u2010weighted images. Tumour tissue consisted of cords and nests of pigment epithelium cells separated by septa of vascularized fibrous connective tissue, leading to a pseudo\u2010glandular appearance. The melanin granules in the cytoplasm were large and mostly spherical in shape. In four patients, the tumours were hyperpigmented. Tumour cells were large with round or oval nuclei and clearly detectable nucleoli.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These clinical characteristics of <jats:styled-content style=\"fixed-case\">CPE<\/jats:styled-content> adenomas, such as homogenous dark brown colour, smooth surface, iris dislocation and anterior chamber angle narrowing but no iris infiltration, segmental cataract, pigment dispersion, and, as compared to brain tissue, hypointensity and, as compared to extraocular muscles or lacrimal gland, hyperintensity on T2\u2010weighted <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> images, may be helpful for the differentiation from ciliary body malignant melanomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13029","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T09:52:35Z","timestamp":1462096355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical and histopathological features of adenomas of the ciliary pigment epithelium"],"prefix":"10.1111","volume":"94","author":[{"given":"Ying","family":"Chang","sequence":"first","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Tong","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Fang","family":"Xian","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Xia","family":"Bai","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University, Beijing Ophthalmology &amp; Visual Sciences Key Laboratory Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim Ruprecht\u2010Karls\u2010University of Heidelberg Seegartenklinik Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01556.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1559-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ophtha.2010.11.011","article-title":"Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases","volume":"118","author":"Bianciotto C","year":"2011","journal-title":"Ophthalmology"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(79)90750-5"},{"key":"e_1_2_5_6_1","first-page":"360","article-title":"Ciliary body melanoma \u2013 a particularly rare type of ocular tumor. Case report and general considerations","volume":"8","author":"Costache M","year":"2013","journal-title":"Maedica (Buchar)"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.4.504"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33568-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72221-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1991.tb04835.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1999.770622.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2004.00330.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1999.770423.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01889.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32375-8"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.9549"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00151-7"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.048967"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.6.484"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30394-1"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30393-X"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.5.592"},{"key":"e_1_2_5_23_1","first-page":"1859","article-title":"Clinicopathologic reports, case reports, and small case series: progressive growth of benign adenoma of the pigment epithelium of the ciliary body","volume":"119","author":"Shields JA","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.217"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000445"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170100353"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01765.x"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13029","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T20:33:30Z","timestamp":1694896410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,29]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/aos.13029"],"URL":"https:\/\/doi.org\/10.1111\/aos.13029","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,29]]},"assertion":[{"value":"2015-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}