{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:24Z","timestamp":1792787004736,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"State Academy of Science of Republic Bashkortostan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To compare the results of standard corneal crosslinking (\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      ) and transepithelial iontophoresis\u2010assisted\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      after 24\u00a0months follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      Corneal crosslinking (CXL) was performed in a series of 149 eyes of 119 patients with keratoconus I\u2013II of Amsler classification. Depending on the\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      method, patients were divided into two groups: (1) 73 eyes with standard\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      and (2) 76 eyes with transepithelial iontophoresis\u2010assisted\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      . Depending on the group, epithelium removal or administration of riboflavin solution by iontophoresis for 10\u00a0min was performed, after which standard surface\n                      <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                      irradiation (370\u00a0nm, 3\u00a0mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) was performed at a 5\u2010cm distance for 30\u00a0min.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A statistically significant difference in corrected distance visual acuity (\n                      <jats:styled-content style=\"fixed-case\">CDVA<\/jats:styled-content>\n                      ) was observed between the two groups, with a better outcome in the second group after 6\u00a0months (p\u00a0=\u00a00.037); however, no significant difference was found 24\u00a0months after treatment (p\u00a0=\u00a00.829). Stabilization and regression of keratometry values were achieved in both groups, but standard\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      was more effective. The average demarcation line depth in the standard\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      group was 292\u00a0\u00b1\u00a014\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m after 14\u00a0days and 172\u00a0\u00b1\u00a016\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m in the transepithelial iontophoresis\u2010assisted\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      group. No demarcation line was detected after 1\u00a0month and 3\u00a0months in 45% and 100% of the eyes in the second group respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Transepithelial iontophoresis\u2010assisted collagen crosslinking showed to be less effective than standard\n                      <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>\n                      after 24\u00a0months of follow\u2010up, possibly due to a more superficial formation of corneal collagen crosslinks, however the stopping of disease progression was achieved 24\u00a0months after procedure.\n                    <\/jats:p>\n                  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