{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:10:25Z","timestamp":1774023025579,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To report the 5\u2010year incidence of visual impairment after mitomycin C\u2010augmented trabeculectomy (<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> trabeculectomy) and the risk factors for visual impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicentre prospective observational cohort study. Among glaucoma patients registered in the Collaborative Bleb\u2010related Infection Incidence and Treatment Study performed in Japan, the patients with eyes meeting the following qualifications were included: eyes with primary open\u2010angle glaucoma; eyes with primary angle\u2010closure glaucoma; eyes with exfoliative glaucoma; eyes with \u22653\/60 in blindness analysis; and eyes with \u226520\/60 in low\u2010vision analysis and visual acuity loss analysis. The patients were followed at 6\u2010month intervals for 5\u00a0years. The entry data and follow\u2010up data were analysed to determine the incidence of blindness (&lt;3\/60), low vision (\u22653\/60 and &lt;20\/60) and visual acuity loss (\u22650.2 log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content>) during the follow\u2010up period. Risk factors for visual impairment were also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 694 eyes of 694 or 559 eyes of 559 glaucoma patients were subjected to the blindness analysis or the low\u2010vision and visual acuity loss analysis, respectively. Visual acuity significantly deteriorated (p\u00a0&lt;\u00a00.0001): 12.2% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 9.8\u201314.7%) of the patients became blind; 12.1% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 9.4\u201314.9%) were judged to have low vision at the final examination; 28.3% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 24.5\u201332.0%) were judged to have visual acuity loss. Glaucoma subtypes, poor preoperative visual function and postoperative complications are the main risk factors for visual impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Visual acuity was significantly reduced after <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> trabeculectomy in 5\u00a0years, and we identified several risk factors associated with this complication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13058","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T05:12:46Z","timestamp":1462770766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C"],"prefix":"10.1111","volume":"94","author":[{"given":"Kenji","family":"Kashiwagi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of 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